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. 2024 May 10;10(10):e30998.
doi: 10.1016/j.heliyon.2024.e30998. eCollection 2024 May 30.

Influence of periodontal status on patients undergoing hematopoietic stem cell transplantation: A retrospective analysis

Xuan Gao  1 , Shengnan Zhao  1 , Shuting Wang  1 , Yang Sun  1 , Chengzhi Gao  1
Affiliations

Influence of periodontal status on patients undergoing hematopoietic stem cell transplantation: A retrospective analysis

Xuan Gao et al. Heliyon. .

Abstract

Objective: This retrospective analysis aimed to evaluate the prevalence of periodontitis in patients undergoing hematopoietic stem cell transplantation, and investigate the effects of various periodontal statuses and risk factors on oral infection incidence.

Study design: Medical records of patients pre- and post-hematopoietic stem cell transplantation from June 2019 to October 2021were reviewed. The study examined the effort of different periodontal statuses on oral complications and infections in patients during transplantation.

Results: Of 549 transplant patients studied, 363 had periodontitis. Patients with or without periodontitis showed significant differences in mean age, male proportion, and mucositis incidence during transplantation (P < 0.05). Bacteremia rates were slightly higher in patients with periodontitis, but not significant. Male proportion, age, and hospitalization duration significantly increased with advancing periodontitis stages. Only two patients experienced periodontal complications, that were effectively managed and did not interfere in the grafting process.

Conclusion: Periodontitis is prevalent in patients with hematopoietic diseases. Despite its association with oral mucositis, the occurrence of periodontal infection remains low and controllable.

Keywords: Hematopoietic stem cell transplantation; Oral complications; Periodontal disease.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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