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Case Reports
. 2024 May 14;19(8):3180-3184.
doi: 10.1016/j.radcr.2024.04.038. eCollection 2024 Aug.

Case of submandibular schwannoma and review of literature

Bi Ying Xie  1 , Zachary Drew  2 , Dalveer Singh  2 , Gary Quagliotto  3
Affiliations
Case Reports

Case of submandibular schwannoma and review of literature

Bi Ying Xie et al. Radiol Case Rep. .

Abstract

Schwannomas are slow growing, benign tumours arising from Schwann cells. They are usually solitary and are sometimes associated with Neurofibromatosis type 1 and 2. As reported by Okada et al., while approximately 25%-40% of extra-cranial schwannomas occur in the head and neck region, Schwannomas of the oral cavity are very uncommon, accounting for only 1% of all Schwannomas. We report a case of a sublingual schwannoma in a 47-year-old female, discovered incidentally during the workup for tinnitus. The radiological and histopathological findings, along with a literature review, are presented.

Keywords: Floor of mouth; Neuroma; Schwannoma; Sublingual.

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Figures

Fig 1
Fig. 1
Axial post contrast T1. Incidentally detected enhancing lesion left floor of mouth (blue arrow) on MRI brain performed for work-up of tinnitus. Lesion is located at the posterior aspect of the left sublingual gland, and measures 21 × 13 × 20 mm (AP x TR x CC). Central region of non-enhancement within the lesion reflecting an internal cystic component.
Fig 2
Fig. 2
Multisequence MRI floor of mouth. A dedicated contrast MRI of the floor of mouth demonstrates the lesion (blue arrows) to be isointense to muscle on T1 (A) and hyperintense on T2 (B), with intense post contrast enhancement (C, D). The lesion has relatively well circumscribed margins and was not associated with any restricted diffusion or features of local invasion. No further oral cavity lesions or locoregional lymphadenopathy evident.
Fig 3
Fig. 3
H and E stain of the specimen demonstrating spindle cell tumor with Verocay bodies.
Fig 4
Fig. 4
Immunohistochemical staining of lesional cells were diffusely positive for S100 (red chromogen).
See this image and copyright information in PMC

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