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. 2024 Jul;60(7):294-298.
doi: 10.1111/jpc.16568. Epub 2024 May 23.

Gastroschisis and septo-optic-pituitary dysplasia: Is there an association?

Michael S Salman  1 , Chelsea A Ruth  2 , Marina S Yogendran  3 , Anna Zrinyi  4 , Melanie Morris  4
Affiliations

Gastroschisis and septo-optic-pituitary dysplasia: Is there an association?

Michael S Salman et al. J Paediatr Child Health. 2024 Jul.

Abstract

Aim: There are several case reports describing patients with both optic nerve hypoplasia/septo-optic-pituitary dysplasia (ONH/SOD) and gastroschisis (GS). Our aim was to investigate whether ONH/SOD is associated with GS.

Methods: A retrospective population-based study was undertaken using the Population Research Data Repository at the Manitoba Center for Health Policy in Manitoba, Canada to investigate if any patient with ONH/SOD also had GS. In addition, Winnipeg's Surgical Database of Outcomes and Management (WiSDOM), a hospital-based paediatric surgical database, was searched to ascertain if any of the patients with GS also have ONH/SOD.

Results: Cases were 124 patients with ONH/SOD diagnosed during 1990-2019. None had GS. The surgical database had 188 patients from Manitoba with GS during 1991-2019. None had ONH/SOD.

Conclusion: There does not appear to be an association between ONH/SOD and GS in our cohorts of patients with these two disorders.

Keywords: case control study; congenital anomaly; gastroschisis; optic nerve hypoplasia; paediatrics.

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References

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