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Meta-Analysis
. 2024 Jul;26(7):325-337.
doi: 10.1007/s11906-024-01306-3. Epub 2024 May 23.

Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis

Min Xu #  1   2   3   4   5 , Hai-Xia Wang #  1   2   3   4 , Ping Zu  1   2   3   4 , Nan Jiang  1   2   3   4 , Jing-Feng Bian  1   2   3   4 , Ji-Rong Xu  1   2   3   4 , Wei Luo  1   2   3   4 , Peng Zhu  6   7   8   9   10
Affiliations
Meta-Analysis

Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis

Min Xu et al. Curr Hypertens Rep. 2024 Jul.

Abstract

Purpose of review: Pregnancy-induced preeclampsia is a severe pregnancy complication and preeclampsia has been associated with an increased risk of chronic hypertension for offspring. However, the magnitude of the overall effect of exposure to preeclampsia in pregnancy on blood pressure (BP) in offspring is unknown. This systematic review and meta-analysis was sought to systematically assess the effects of preeclampsia on the BP of the offspring.

Recent findings: Of 2550 publications identified, 23 studies were included. The meta-analysis indicated that preeclampsia increases the potential risk of hypertension in offspring. Systolic blood pressure (SBP) was 2.0 mm Hg (95% CI: 1.2, 2.8) and diastolic blood pressure (DBP) was 1.4 mm Hg (95% CI: 0.9, 1.9) higher in offspring exposed to pre-eclampsia in utero, compared to those born to normotensive mothers. The correlations were similar in stratified analyses of children and adolescents by sex, geographic area, ages, and gestational age. During childhood and young adulthood, the offspring of pregnant women with preeclampsia are at an increased risk of high BP. It is crucial to monitor their BP.

Keywords: Ages; Areas; Blood pressure; Gestational age; Meta-analysis; Offspring; Preeclampsia; Sexes; Systematic review.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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