Conflict of Interest Disclosures: Dr Qato reported being a consultant for WHO Sexual and Reproductive Health Unit and Public Citizen’s Health Research Group outside the submitted work. Dr Goldman reported receiving grants from National Institute on Aging (R01AG059234) during the conduct of the study; grants from Blue Cross Blue Shield of Arizona, Bristol Myers Squibb, Cedars-Sinai Health System, Edwards Lifesciences, Gates Ventures, Genentech, Gilead Sciences, Johnson & Johnson, Novartis, Pfizer, Roche, Walgreens Boots Alliance, National Institute on Aging (P30AG066589, P30AG024968, P30AG043073, U01AG073697, R01AG062277, R01AG059234), NIDDK (R01DK107552); personal fees from National Railway Labor Conference, Biogen, and GRAIL as a scientific advisory board member; and being a cofounder with equity of EntityRisk outside the submitted work. Dr Fendrick reported being a consultant for AbbVie, CareFirst BlueCross BlueShield, Centivo, Community Oncology Alliance, Covered California, EmblemHealth, EBRI, Elektra Health, Exact Sciences, GRAIL, Harvard University, Health at Scale Technologies, Hopewell Fund, Johnson & Johnson, Medtronic, MedZed, Merck, Mother Goose Health, Phathom Pharmaceuticals, Proton Intelligence, RA Capital, Sempre Health, the state of Minnesota, US Department of Defense, Virginia Center for Health Innovation, Washington Health Benefit Exchange, Wellth, Yale New Haven Health System, and Zansors; receiving research support from the Agency for Healthcare Research and Quality, Gary and Mary West Health Policy Center, Arnold Ventures, National Pharmaceutical Council, Patient-Centered Outcomes Research Institute, Pharmaceutical Research and Manufacturers of America, Robert Wood Johnson Foundation, state of Michigan, and Centers for Medicare & Medicaid Services; serving as co–editor in chief of the American Journal of Managed Care; and being a partner in VBIDHealth, LLC. No other disclosures were reported.