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. 2024 Sep;39(8):512-520.
doi: 10.1177/02683555241256543. Epub 2024 May 23.

Treatment of vascular leg ulcers with leukocyte- and platelet-rich fibrin (L-PRF): A systematic review

Amirali Barzegar Amin  1 , Dries Dorpmans  1 , Hozan Mufty  1   2 , Inge Fourneau  1   2
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Treatment of vascular leg ulcers with leukocyte- and platelet-rich fibrin (L-PRF): A systematic review

Amirali Barzegar Amin et al. Phlebology. 2024 Sep.

Abstract

Objectives: This systematic review aimed to assess the efficacy of Leukocyte- and Platelet-Rich Fibrin (L-PRF) for the treatment of vascular leg ulcers. Method: Following PRISMA guidelines, a literature search was done for studies where L-PRF was used to treat vascular leg ulcers. Results: Among six included articles, a total of 76 venous leg ulcers were treated with L-PRF. None of the studies included ulcers of arterial or lymphatic origin. Fifty-seven (75.0%) of the venous ulcers completely healed at end of follow-up. Mean time to complete healing was 6.7 weeks (SD = 5.0). All non-healed ulcers showed an important reduction in wound area. No adverse effects related to L-PRF therapy were reported. Conclusions: The results suggest that L-PRF could be a safe, simple to use and effective therapeutic option for the treatment of venous leg ulcers, however, caution is advised as the results are based on small sample sizes.

Keywords: Platelet-rich fibrin; leg ulcer; wound healing.

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Conflict of interest statement

Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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