Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 May 9:15:1348127.
doi: 10.3389/fphar.2024.1348127. eCollection 2024.

Therapeutic potential of berries in age-related neurological disorders

Narges Norouzkhani #  1 , Shaghayegh Afshari #  2 , Sayedeh-Fatemeh Sadatmadani #  3 , Mohammad Mahdi Mollaqasem  4 , Shakila Mosadeghi  2 , Hani Ghadri  4 , Safa Fazlizade  5 , Keyvan Alizadeh  5 , Pouyan Akbari Javar  6 , Hamidreza Amiri  7 , Elaheh Foroughi  3 , Arina Ansari  8 , Kourosh Mousazadeh  9 , Bozorgmehr Abdullahzadeh Davany  10 , Ata Akhtari Kohnehshahri  11 , Alaleh Alizadeh  12 , Parisa Alsadat Dadkhah  13 , Mohadeseh Poudineh #  14
Affiliations
Review

Therapeutic potential of berries in age-related neurological disorders

Narges Norouzkhani et al. Front Pharmacol. .

Abstract

Aging significantly impacts several age-related neurological problems, such as stroke, brain tumors, oxidative stress, neurodegenerative diseases (Alzheimer's, Parkinson's, and dementia), neuroinflammation, and neurotoxicity. Current treatments for these conditions often come with side effects like hallucinations, dyskinesia, nausea, diarrhea, and gastrointestinal distress. Given the widespread availability and cultural acceptance of natural remedies, research is exploring the potential effectiveness of plants in common medicines. The ancient medical system used many botanical drugs and medicinal plants to treat a wide range of diseases, including age-related neurological problems. According to current clinical investigations, berries improve motor and cognitive functions and protect against age-related neurodegenerative diseases. Additionally, berries may influence signaling pathways critical to neurotransmission, cell survival, inflammation regulation, and neuroplasticity. The abundance of phytochemicals in berries is believed to contribute to these potentially neuroprotective effects. This review aimed to explore the potential benefits of berries as a source of natural neuroprotective agents for age-related neurological disorders.

Keywords: age-related neurological disease; aging; berry fruits; complementary medicine; treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Main component of Berries.
FIGURE 2
FIGURE 2
The underlying mechanism of therapeutic effects of Berries on Age-related neurological conditions; Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Cerebral ischemia, Cerebrovascular diseases, Atherosclerosis, High Blood Viscosity Syndrome, Epilepsy, Memory loss, Neurodevelopmental disorders, Brain aging. symbols " ↑ " and "↓" are to demonstrate increase/stimulation and decrease/suppression respectively. Abbreviations: Aβ: amyloid-β, BDNF: Brain-derived neurotrophic factor, AChE: acetylcholinesterase, DA: Dopaminergic, ROS: Reactive oxygen species, NRF: The nuclear factor-erythroid–related factor 2, ARE: antioxidant responsive element, NO: Nitric oxide, MDA: Malondialdehyde, IL: Interleukin, TNF: Tumor necrosis factor, HIF: Hypoxia-inducible factor, mPTP: Mitochondrial permeability transition pore, eNOS: Endothelial nitric oxide synthase, ACE: Angiotensin-converting enzyme, AMPK: Adenosine monophosphate (AMP)-activated protein kinase, PGC-1α: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, TrKB: Tropomyosin-related kinase receptor B, Akt: Protein kinase B.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Abbasi E., Nassiri-Asl M., Shafeei M., Sheikhi M. (2012). Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats. Chem. Biol. Drug Des. 80 (2), 274–278. 10.1111/j.1747-0285.2012.01400.x - DOI - PubMed
    1. Abd El Mohsen M. M., Kuhnle G., Rechner A. R., Schroeter H., Rose S., Jenner P., et al. (2002). Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. Free Radic. Biol. Med. 33 (12), 1693–1702. 10.1016/s0891-5849(02)01137-1 - DOI - PubMed
    1. Aggarwal A., Gaur V., Kumar A. (2010). Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. Life Sci. 86 (25-26), 928–935. 10.1016/j.lfs.2010.04.011 - DOI - PubMed
    1. Aggarwal N. T., Wilson R. S., Beck T. L., Rajan K. B., De Leon C. F. M., Evans D. A., et al. (2014). Perceived stress and change in cognitive function among adults 65 years and older. Psychosom. Med. 76 (1), 80–85. 10.1097/PSY.0000000000000016 - DOI - PMC - PubMed
    1. Alfaris N., Alshammari G., Altamimi J., Aljabryn D., Alagal R., Aldera H., et al. (2021). Ellagic acid prevents streptozotocin-induced hippocampal damage and memory loss in rats by stimulating Nrf2 and nuclear factor-κB, and activating insulin receptor substrate/PI3K/Akt axis. J. Physiology Pharmacol. Official J. Pol. Physiological Soc. 72 (4). 10.26402/jpp.2021.4.02 - DOI - PubMed

LinkOut - more resources