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Review
. 2024 May 9:15:1348127.
doi: 10.3389/fphar.2024.1348127. eCollection 2024.

Therapeutic potential of berries in age-related neurological disorders

Narges Norouzkhani #  1 , Shaghayegh Afshari #  2 , Sayedeh-Fatemeh Sadatmadani #  3 , Mohammad Mahdi Mollaqasem  4 , Shakila Mosadeghi  2 , Hani Ghadri  4 , Safa Fazlizade  5 , Keyvan Alizadeh  5 , Pouyan Akbari Javar  6 , Hamidreza Amiri  7 , Elaheh Foroughi  3 , Arina Ansari  8 , Kourosh Mousazadeh  9 , Bozorgmehr Abdullahzadeh Davany  10 , Ata Akhtari Kohnehshahri  11 , Alaleh Alizadeh  12 , Parisa Alsadat Dadkhah  13 , Mohadeseh Poudineh #  14
Affiliations
Review

Therapeutic potential of berries in age-related neurological disorders

Narges Norouzkhani et al. Front Pharmacol. .

Abstract

Aging significantly impacts several age-related neurological problems, such as stroke, brain tumors, oxidative stress, neurodegenerative diseases (Alzheimer's, Parkinson's, and dementia), neuroinflammation, and neurotoxicity. Current treatments for these conditions often come with side effects like hallucinations, dyskinesia, nausea, diarrhea, and gastrointestinal distress. Given the widespread availability and cultural acceptance of natural remedies, research is exploring the potential effectiveness of plants in common medicines. The ancient medical system used many botanical drugs and medicinal plants to treat a wide range of diseases, including age-related neurological problems. According to current clinical investigations, berries improve motor and cognitive functions and protect against age-related neurodegenerative diseases. Additionally, berries may influence signaling pathways critical to neurotransmission, cell survival, inflammation regulation, and neuroplasticity. The abundance of phytochemicals in berries is believed to contribute to these potentially neuroprotective effects. This review aimed to explore the potential benefits of berries as a source of natural neuroprotective agents for age-related neurological disorders.

Keywords: age-related neurological disease; aging; berry fruits; complementary medicine; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Main component of Berries.
FIGURE 2
FIGURE 2
The underlying mechanism of therapeutic effects of Berries on Age-related neurological conditions; Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Cerebral ischemia, Cerebrovascular diseases, Atherosclerosis, High Blood Viscosity Syndrome, Epilepsy, Memory loss, Neurodevelopmental disorders, Brain aging. symbols " ↑ " and "↓" are to demonstrate increase/stimulation and decrease/suppression respectively. Abbreviations: Aβ: amyloid-β, BDNF: Brain-derived neurotrophic factor, AChE: acetylcholinesterase, DA: Dopaminergic, ROS: Reactive oxygen species, NRF: The nuclear factor-erythroid–related factor 2, ARE: antioxidant responsive element, NO: Nitric oxide, MDA: Malondialdehyde, IL: Interleukin, TNF: Tumor necrosis factor, HIF: Hypoxia-inducible factor, mPTP: Mitochondrial permeability transition pore, eNOS: Endothelial nitric oxide synthase, ACE: Angiotensin-converting enzyme, AMPK: Adenosine monophosphate (AMP)-activated protein kinase, PGC-1α: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, TrKB: Tropomyosin-related kinase receptor B, Akt: Protein kinase B.
See this image and copyright information in PMC

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