Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 May 20;2024(5):omae050.
doi: 10.1093/omcr/omae050. eCollection 2024 May.

Adenoid cystic/basal-cell carcinoma of the prostate following high-grade urothelial bladder cancer: a case report

Maja Sofronievska Glavinov  1 , Blagica Krsteska  2 , Vita Stojmenova  3 , Tanja Petrovska  4 , Rubens Jovanovic  2
Affiliations
Case Reports

Adenoid cystic/basal-cell carcinoma of the prostate following high-grade urothelial bladder cancer: a case report

Maja Sofronievska Glavinov et al. Oxf Med Case Reports. .

Abstract

Adenoid cystic/Basal-cell carcinoma (ACC/BCC) of the prostate is a rare histological type exhibiting various morphological characteristics and an optimal treatment has not yet been established. We report the case of a 63-year-old patient who complained of incomplete bladder emptying and recurrent urinary infection six months after transurethral resection of a high-grade urothelial bladder tumor. The clinical features, digital rectal examination, serum PSA levels, and multiparametric MRI did not refer to any suspicious prostatic lesions and cystoscopy revealed bladder neck hypertrophy, and yellowish zones in the prostatic urethra. Transurethral resection was performed due to these findings and histopathological analysis showed poorly differentiated ACC/BCC of the prostate. Even though there is no proven mutual correlation between ACC/BCC and urothelial bladder cancer, the appearance of obstructive urinary symptoms, bladder-neck hypertrophy, and macroscopic changes in prostatic urethra should be reconsidered for transurethral resection biopsy considering the possibility of ACC/BCC.

Keywords: adenoid cystic/basal cell carcinoma; bladder; case report; prostate; urothelial carcinoma.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest.

Figures

Figure 1
Figure 1
MRI findings in normal ranges A. T2-weighted imaging (T2WI), B. diffusion-weighted imaging (DWI), C. ADC map and Dynamic contrast enhancement (DCE), D.T1-weighted fast spoiled gradient echo.
Figure 2
Figure 2
A. Bladder neck endoscopic visual, upper arrow pointing to the place of previously resected bladder tumor; lower arrow pointing to a new lesion of bladder neck before TUR, B. bladder neck and prostate after TUR.
Figure 3
Figure 3
Basal-cell/adenoid cystic carcinoma; A. HeEo staining (40×) B. HeEo staining (100×).
Figure 4
Figure 4
Immunohistochemical positive staining for; A. CKHMW (100×) B. CK7 (100×).
Figure 5
Figure 5
Immunohistochemical partially positive staining for A. p63 (100×), B.PSA (100×).
Figure 6
Figure 6
Skeletal scintigraphy with 99mTc-MDP showing the tracer’s inhomogeneous distribution in the spinal column’s thoracic segment, with emphasized activity in the projection of the eight thoracic vertebrae (arrow).
See this image and copyright information in PMC

References

    1. Cozzi S, Bardoscia L, Najafi M, Botti A, Blandino G, Augugliaro M. et al. . Adenoid cystic carcinoma/basal cell carcinoma of the prostate: overview and update on rare prostate cancer subtypes. Curr Oncol 2022;29:1866–76. - PMC - PubMed
    1. Julka PK. Adenoid cystic carcinoma of the prostate: an unusual subtype of prostate cancer. J Transl Genet Genom 2020;4:455–63.
    1. Ryan P, Kelly C, Shanahan S, Jordan KE, Daly J, Ryan P. Adenoid cystic carcinoma of the prostate-a rare case of genitourinary malignancy. Urol Case Rep 2022;42:1020–5. - PMC - PubMed
    1. Taskovska M, Frelih M, Smrkolj T, Volavšek M. Basal cell carcinoma of the prostate misdiagnosed as high-grade urothelial cancer - a case report of a diagnostic pitfall. Res Rep Urol 2023;15:187–92. - PMC - PubMed
    1. Chang K, Dai B, Kong Y, Qu Y, Wu J, Ye D. Basal cell carcinoma of the prostate: clinicopathologic analysis of three cases and a review of the literature. World J Surg Oncol 2013;11:193–3. - PMC - PubMed

Publication types