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Review
. 2024 May 7;12(5):127.
doi: 10.3390/dj12050127.

Leveraging Dental Stem Cells for Oral Health during Pregnancy: A Concise Review

Aida Meto  1   2   3 , Ana Sula  4 , Samuele Peppoloni  2 , Agron Meto  1 , Elisabetta Blasi  2
Affiliations
Review

Leveraging Dental Stem Cells for Oral Health during Pregnancy: A Concise Review

Aida Meto et al. Dent J (Basel). .

Abstract

Pregnancy induces significant changes in oral health because of hormonal fluctuations, making it a crucial period for preventive measures. Dental stem cells (DSCs), particularly those derived from the dental pulp and periodontal ligaments, offer promising avenues for regenerative therapies and, possibly, preventive interventions. While the use of DSCs already includes various applications in regenerative dentistry in the general population, their use during pregnancy requires careful consideration. This review explores recent advancements, challenges, and prospects in using DSCs to address oral health issues, possibly during pregnancy. Critical aspects of the responsible use of DSCs in pregnant women are discussed, including safety, ethical issues, regulatory frameworks, and the need for interdisciplinary collaborations. We aimed to provide a comprehensive understanding of leveraging DSCs to improve maternal oral health.

Keywords: dental stem cells; ethics; gingivitis; hormonal changes; maternal-fetal health; oral microbiota; periodontitis; pregnancy; regenerative dentistry; safety.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Scheme 1
Scheme 1
Potential impact of pregnancy on DSCs. Different lines of research will have to be developed to expand the knowledge on each specific issue.
See this image and copyright information in PMC

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