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. 2024 May 9;12(5):135.
doi: 10.3390/dj12050135.

Platelet-Rich Fibrin in Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial

Simran R Parwani  1 , Kaustubh S Thakare  1 , Kshipra P Kawadkar  1 , Nishita Jaju Soni  1 , Rajkumar Parwani  2 , Himanshu Dadlani  3   4 , Dhanashree S Chaudhary  1 , Dipanshu Pahuja  1 , Gianrico Spagnuolo  5   6 , Niccolò Giuseppe Armogida  5
Affiliations

Platelet-Rich Fibrin in Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial

Simran R Parwani et al. Dent J (Basel). .

Abstract

This clinical trial investigated the efficacy of platelet-rich fibrin (PRF) as an adjunct to conventional scaling and root planing (SRP) in non-surgical periodontal therapy. In a split-mouth randomized controlled trial with 13 patients and 26 periodontal pocket sites, PRF was inserted in test group pockets alongside SRP, while control group pockets received SRP alone. Measurements at baseline and six weeks included probing pocket depths (PPDs), clinical attachment loss (CAL), gingival recession (GR), the plaque index, and the gingivitis index. The wound healing index was assessed at six weeks. The results show statistically significant improvements in the SRP+PRF group compared to SRP alone, demonstrating a better CAL gain (SRP+PRF group: 2.69 ± 0.63; SRP alone group: 4.15 ± 0.69-p-value: 0.001), PPD reduction (SRP+PRF group: 2.62 ± 0.65; SRP alone group: 3.85 ± 0.80-p-value: 0.001), and GR minimization (SRP+PRF group: 0.46 ± 0.62; SRP alone group: 0.81 ± 0.72-p-value: 0.21). The adjunctive use of PRF enhanced healing, reduced pocket depths, decreased tissue morbidity, and minimized gingival recession. This study concludes that PRF placement is effective in 5-6 mm pockets, potentially reducing the number of periodontal treatment sessions needed for pocket closure.

Keywords: periodontal pocket; periodontitis; platelet-rich fibrin; scaling and root planing.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRF preparation.
Figure 2
Figure 2
Sterile plastic tubes with the centrifuged blood sample.
Figure 3
Figure 3
PRF fibrin clot.
Figure 4
Figure 4
PRF fibrin membrane.
Figure 5
Figure 5
Group 2 (test) procedure: site after the SRP (A), PRF membrane cut and applied to the periodontal pocket and fixed with a suture (B), healing and suture removal after one week (C), and at the 6-week follow-up (D).
Figure 6
Figure 6
Consort flow diagram: sample size with affected sites, treatment protocol, and its outcome.
See this image and copyright information in PMC

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