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. 2024 May 2;11(5):143.
doi: 10.3390/jcdd11050143.

Association between Abdominal Aortic Calcification and Coronary Heart Disease in Essential Hypertension: A Cross-Sectional Study from the 2013-2014 National Health and Nutrition Examination Survey

Lan He  1 , Xu Li  1 , E Shen  2 , Yong-Ming He  1
Affiliations

Association between Abdominal Aortic Calcification and Coronary Heart Disease in Essential Hypertension: A Cross-Sectional Study from the 2013-2014 National Health and Nutrition Examination Survey

Lan He et al. J Cardiovasc Dev Dis. .

Abstract

Background: This study aimed to investigate the association between abdominal aortic calcification (AAC) and coronary heart disease (CHD) in essential hypertension (EH).

Methods: This study included patients diagnosed with EH during the 2013-2014 NHANES survey cycle. The study cohort was categorized into the following four groups based on their AAC-24 score: no AAC (0); mild AAC (1-4); moderate AAC (5-15); and severe AAC (16-24). Logistic regression models were used to assess the association between AAC and CHD. Restricted cubic spline curves (RCS) were used to explore possible nonlinear relationships between AAC and CHD.

Results: The prevalence of CHD was found to be higher in the moderate AAC and severe AAC groups than in the group without AAC (40.1% versus 30.9%, 47.7% versus 30.9%). On a continuous scale, the fully adjusted model showed a 7% increase in the risk of CHD prevalence per score increase in AAC [OR (95% CI) = 1.07 (1.03-1.11)]. On a categorical scale, the fully adjusted model showed the risk of CHD prevalence in EH patients with moderate AAC and severe AAC was 2.06 (95%CI, 1.23-3.45) and 2.18 (1.09-5.25) times higher than that in patients without AAC, respectively. The RCS curve suggested a dose-response linear relationship between AAC and CHD.

Conclusion: These findings highlight that in patients with EH, a higher severity of AAC is associated with a higher risk of CHD prevalence.

Keywords: abdominal aortic calcification; coronary heart disease; essential hypertension.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of participant selection. Abbreviations: EH = essential hypertension; AAC = abdominal aortic calcification; and CHD = coronary heart disease.
Figure 2
Figure 2
RCS curves for examining the nonlinear relationship between AAC score and CHD.
Figure 3
Figure 3
The results showed the OR (95% CI) of moderate AAC in different subgroups when without AAC was used as a reference. Subgroup analysis was adjusted for all variables as shown in Model 4 in Table 2. Abbreviations: OR = odds ratio; CI = confidence interval; and P-int = P-interaction.
See this image and copyright information in PMC

References

    1. Bonarjee V.V.S. Arterial Stiffness: A Prognostic Marker in Coronary Heart Disease. Available Methods and Clinical Application. Front. Cardiovasc. Med. 2018;5:64. doi: 10.3389/fcvm.2018.00064. - DOI - PMC - PubMed
    1. Mortensen M.B., Dzaye O., Bodtker H., Steffensen F.H., Botker H.E., Jensen J.M., Ronnow Sand N.P., Maeng M., Warnakula Olesen K.K., Sorensen H.T., et al. Interplay of Risk Factors and Coronary Artery Calcium for CHD Risk in Young Patients. JACC Cardiovasc. Imaging. 2021;14:2387–2396. doi: 10.1016/j.jcmg.2021.05.003. - DOI - PubMed
    1. Polonskaya Y.V., Kashtanova E.V., Murashov I.S., Striukova E.V., Kurguzov A.V., Stakhneva E.M., Shramko V.S., Maslatsov N.A., Chernyavsky A.M., Ragino Y.I. Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD. J. Pers. Med. 2021;11:506. doi: 10.3390/jpm11060506. - DOI - PMC - PubMed
    1. Zhang H., Li G., Yu X., Yang J., Jiang A., Cheng H., Fu J., Liang X., Liu J., Lou J., et al. Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis. JAMA Netw. Open. 2023;6:e2310909. doi: 10.1001/jamanetworkopen.2023.10909. - DOI - PMC - PubMed
    1. Bastos Goncalves F., Voute M.T., Hoeks S.E., Chonchol M.B., Boersma E.E., Stolker R.J., Verhagen H.J. Calcification of the abdominal aorta as an independent predictor of cardiovascular events: A meta-analysis. Heart. 2012;98:988–994. doi: 10.1136/heartjnl-2011-301464. - DOI - PubMed

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