Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 1;141(2):408-410.
doi: 10.1097/ALN.0000000000005034.

Intraoperative Methadone and Postoperative Anesthesia Care Unit Outcomes: A Retrospective Cohort Analysis

Affiliations

Intraoperative Methadone and Postoperative Anesthesia Care Unit Outcomes: A Retrospective Cohort Analysis

Evan D Kharasch. Anesthesiology. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: None

Figures

Figure.
Figure.
PACU outcomes after anesthesia with or without intraoperative methadone. A) PACU Phase 1 length of stay. Results are medians and 25th-75th percentiles. B) PACU antiemetic administration as a surrogate indicator of PONV. Results are means ± SD. Medians were zero for all groups. C) PACU naloxone administration as a surrogate indicator of respiratory depression. Subject numbers in each group are shown in the panels.

Similar articles

Cited by

References

    1. Kharasch ED: Intraoperative methadone: rediscovery, reappraisal, and reinvigoration? Anesth Analg 2011;112:13–6 - PMC - PubMed
    1. Murphy GS, Szokol JW: Intraoperative methadone in surgical patients: A review of clinical investigations. Anesthesiology 2019;131:678–692 - PubMed
    1. Machado FC, Vieira JE, de Orange FA, Ashmawi HA: Intraoperative methadone reduces pain and opioid consumption in acute postoperative pain: A systematic review and meta-analysis. Anesth Analg 2019;129:1723–1732 - PubMed
    1. Boisvert-Plante V, Poulin-Harnois C, Ingelmo P, Einhorn LM: What we know and what we don’t know about the perioperative use of methadone in children and adolescents. Paediatr Anaesth 2023;33:185–192 - PMC - PubMed
    1. Komen H, Brunt LM, Deych E, Blood J, Kharasch ED: Intraoperative methadone in same-day ambulatory surgery: A randomized, double-blinded, dose-finding pilot study. Anesth Analg 2019;128:802–810 - PMC - PubMed