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Case Reports
. 2024;14(5):1061-1069.
doi: 10.3233/JPD-230426.

Mycobacterium bovis Infection of a Deep Brain Stimulation System Following Intravesical Bacillus Calmette-Guérin (BCG) Instillation

Linda E Spruijt  1 , Arne Mosch  1 , Carel F E Hoffmann  2 , Cees van Nieuwkoop  3 , Jasper D Tijsterman  4 , Rodi Zutt  1 , Niels A van der Gaag  2   5 , M Fiorella Contarino  1   6
Affiliations
Case Reports

Mycobacterium bovis Infection of a Deep Brain Stimulation System Following Intravesical Bacillus Calmette-Guérin (BCG) Instillation

Linda E Spruijt et al. J Parkinsons Dis. 2024.

Abstract

Deep brain stimulation (DBS) is an advanced treatment in Parkinson's disease. We describe a 71-year-old patient in whom the DBS got infected with Mycobacterium bovis shortly after intravesical BCG instillations as an adjuvant treatment of bladder cancer. The DBS internal pulse generator and extension wires had to be replaced, and the patient was treated successfully with rifampicin, isoniazid, and ethambutol during three months. This case suggests that physicians need to be aware of the risk of this kind of infection and add a specific Mycobacterial test to the regular cultures.

Keywords: Bacillus Calmette Guerin; Parkinson’s disease; deep brain stimulation; infection; mycobacterium bovis.

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Conflict of interest statement

Dr. Contarino: Advisory board/consultancies (all fees to institution): Inbrain, Medtronic Boston Scientific; Speaking fees: ECMT, Boston Scientific; Research support/contracted research: Boston Scientific.

All other authors have no conflict of interest to report.

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