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. 1985:405 Suppl 1:S2-7.
doi: 10.1007/BF00581771.

Volume regulation and basolateral co-transport of sodium, potassium, and chloride ions in frog skin epithelium

H H Ussing

Volume regulation and basolateral co-transport of sodium, potassium, and chloride ions in frog skin epithelium

H H Ussing. Pflugers Arch. 1985.

Abstract

Frog skin epithelium, which is normally almost tight to chloride, acquires a basolateral leakiness to chloride during osmotic swelling. By measuring the epithelial thickness (volume) after equilibration first with half thiocyanate Ringer, and then full thiocyanate Ringer, one obtains the chloride-free volume. Partial or full recovery of the volume and cellular chloride concentration occurs only when the inside of the skin is exposed to solutions containing K as well as Na and Cl. This recovery process is totally inhibited by low concentrations of bumetanide. The data suggest a basolateral NaKCl2 co-transport.

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