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Review
. 2024 May 11;11(5):581.
doi: 10.3390/children11050581.

A Comprehensive Look at the Development of Asthma in Children

Ileana Diana Diaconu  1 , Veronica Gheorman  2 , Gabriela Adriana Grigorie  3 , Cristian Gheonea  4 , Tiberiu-Stefanita Tenea-Cojan  5 , Beatrice Mahler  6 , Ion Alexandru Voropanov  7 , Mihnea Cristian Firoiu  8 , Andreea Silvia Pîrvu  9 , Alexandru Bogdan Popescu  10 , Renata Văruț  11
Affiliations
Review

A Comprehensive Look at the Development of Asthma in Children

Ileana Diana Diaconu et al. Children (Basel). .

Abstract

Asthma, a prevalent chronic respiratory condition affecting millions of children globally, presents a significant health challenge. This review critically examines the developmental pathways of asthma in children, focusing on genetic, environmental, and early-life determinants. Specifically, we explore the impact of prenatal and postnatal factors such as maternal smoking, nutrition, respiratory infections, and allergen exposure on asthma development. Our analysis highlights the intricate interplay of these influences and their contribution to childhood asthma. Moreover, we emphasize targeted strategies and interventions to mitigate its burden, including genetic counseling for at-risk families, environmental modifications to reduce triggers, and early-life immunomodulation. By delving into these preventive measures and interventions, our review aims to provide actionable insights for healthcare professionals in developing tailored strategies to address the complexities of childhood asthma. In summary, this article offers a detailed examination of asthma development in children, aiming to enhance understanding and inform efforts to reduce its burden through targeted interventions.

Keywords: allergen exposure; childhood asthma; early-life influences; environmental factors; genetic predisposition; immunomodulation; maternal smoking; prenatal care; preventive measures; respiratory health.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Evolutionary patterns of childhood asthma based on natural evolution and response to management from phenotype to endotype.
Figure 2
Figure 2
The nexus of genetic predisposition and environmental influences.
Figure 3
Figure 3
Exploring the genetic constellation: unraveling epigenetic changes.
See this image and copyright information in PMC

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