CRISPR-Cas Systems and Genome Editing: Beginning the Era of CRISPR/Cas Therapies for Humans

doi:10.3390/ijms25105292

Editorial

. 2024 May 13;25(10):5292.

doi: 10.3390/ijms25105292.

CRISPR-Cas Systems and Genome Editing: Beginning the Era of CRISPR/Cas Therapies for Humans

Dmitry S Karpov¹

Affiliations

Affiliation

¹ Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str. 32, Moscow 119991, Russia.

PMID: 38791336
PMCID: PMC11121477
DOI: 10.3390/ijms25105292

Editorial

CRISPR-Cas Systems and Genome Editing: Beginning the Era of CRISPR/Cas Therapies for Humans

Dmitry S Karpov. Int J Mol Sci. 2024.

. 2024 May 13;25(10):5292.

doi: 10.3390/ijms25105292.

Author

Dmitry S Karpov¹

Affiliation

¹ Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Str. 32, Moscow 119991, Russia.

PMID: 38791336
PMCID: PMC11121477
DOI: 10.3390/ijms25105292

Abstract

Harnessing of CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated genes) systems for detection, chemical modification, and sequence editing of nucleic acids dramatically changed many fields of fundamental science, biotechnology, and biomedicine [...].

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Conflict of interest statement

The author declares no conflicts of interest. The funders had no role in the design of the study, in the collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.

Figures

**Figure 1**
Selected applications of CRISPR/Cas-based genome editing that are discussed in the Special Issue. Created with BioRender.com.

See this image and copyright information in PMC

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References

1. Ding W., Zhang Y., Shi S. Development and Application of CRISPR/Cas in Microbial Biotechnology. Front. Bioeng. Biotechnol. 2020;8:711. doi: 10.3389/fbioe.2020.00711. - DOI - PMC - PubMed
1. Xu Y., Li Z. CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy. Comput. Struct. Biotechnol. J. 2020;18:2401–2415. doi: 10.1016/j.csbj.2020.08.031. - DOI - PMC - PubMed
1. Ledford H., Callaway E. Pioneers of revolutionary CRISPR gene editing win chemistry Nobel. Nature. 2020;586:346–347. doi: 10.1038/d41586-020-02765-9. - DOI - PubMed
1. Vicente M.M., Chaves-Ferreira M., Jorge JM P., Proenca J.T., Barreto V.M. The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing. Front. Cell Dev. Biol. 2021;9:718466. doi: 10.3389/fcell.2021.718466. - DOI - PMC - PubMed
1. Pourcel C., Touchon M., Villeriot N., Vernadet J.P., Couvin D., Toffano-Nioche C., Vergnaud G. CRISPRCasdb a successor of CRISPRdb containing CRISPR arrays and cas genes from complete genome sequences, and tools to download and query lists of repeats and spacers. Nucleic Acids Res. 2020;48:D535–D544. doi: 10.1093/nar/gkz915. - DOI - PMC - PubMed

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[1] Ding W., Zhang Y., Shi S. Development and Application of CRISPR/Cas in Microbial Biotechnology. Front. Bioeng. Biotechnol. 2020;8:711. doi: 10.3389/fbioe.2020.00711. - DOI - PMC - PubMed

[2] Ding W., Zhang Y., Shi S. Development and Application of CRISPR/Cas in Microbial Biotechnology. Front. Bioeng. Biotechnol. 2020;8:711. doi: 10.3389/fbioe.2020.00711. - DOI - PMC - PubMed

[3] Xu Y., Li Z. CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy. Comput. Struct. Biotechnol. J. 2020;18:2401–2415. doi: 10.1016/j.csbj.2020.08.031. - DOI - PMC - PubMed

[4] Xu Y., Li Z. CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy. Comput. Struct. Biotechnol. J. 2020;18:2401–2415. doi: 10.1016/j.csbj.2020.08.031. - DOI - PMC - PubMed

[5] Ledford H., Callaway E. Pioneers of revolutionary CRISPR gene editing win chemistry Nobel. Nature. 2020;586:346–347. doi: 10.1038/d41586-020-02765-9. - DOI - PubMed

[6] Ledford H., Callaway E. Pioneers of revolutionary CRISPR gene editing win chemistry Nobel. Nature. 2020;586:346–347. doi: 10.1038/d41586-020-02765-9. - DOI - PubMed

[7] Vicente M.M., Chaves-Ferreira M., Jorge JM P., Proenca J.T., Barreto V.M. The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing. Front. Cell Dev. Biol. 2021;9:718466. doi: 10.3389/fcell.2021.718466. - DOI - PMC - PubMed

[8] Vicente M.M., Chaves-Ferreira M., Jorge JM P., Proenca J.T., Barreto V.M. The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing. Front. Cell Dev. Biol. 2021;9:718466. doi: 10.3389/fcell.2021.718466. - DOI - PMC - PubMed

[9] Pourcel C., Touchon M., Villeriot N., Vernadet J.P., Couvin D., Toffano-Nioche C., Vergnaud G. CRISPRCasdb a successor of CRISPRdb containing CRISPR arrays and cas genes from complete genome sequences, and tools to download and query lists of repeats and spacers. Nucleic Acids Res. 2020;48:D535–D544. doi: 10.1093/nar/gkz915. - DOI - PMC - PubMed

[10] Pourcel C., Touchon M., Villeriot N., Vernadet J.P., Couvin D., Toffano-Nioche C., Vergnaud G. CRISPRCasdb a successor of CRISPRdb containing CRISPR arrays and cas genes from complete genome sequences, and tools to download and query lists of repeats and spacers. Nucleic Acids Res. 2020;48:D535–D544. doi: 10.1093/nar/gkz915. - DOI - PMC - PubMed

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CRISPR-Cas Systems and Genome Editing: Beginning the Era of CRISPR/Cas Therapies for Humans

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CRISPR-Cas Systems and Genome Editing: Beginning the Era of CRISPR/Cas Therapies for Humans

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Abstract

Conflict of interest statement

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