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. 1985 Nov;28(5):684-8.
doi: 10.1128/AAC.28.5.684.

In vitro antibacterial activity of Sch 34343 and its stability to beta-lactamases and renal dehydropeptidase 1

K Matsuda, K Sasaki, K Inoue, H Kondo, M Inoue, S Mitsuhashi

In vitro antibacterial activity of Sch 34343 and its stability to beta-lactamases and renal dehydropeptidase 1

K Matsuda et al. Antimicrob Agents Chemother. 1985 Nov.

Abstract

The in vitro antibacterial activity of Sch 34343 against 1,328 strains of clinical isolates was compared with those of imipenem and ceftazidime. Sch 34343 had a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria but was inactive against Pseudomonas aeruginosa and Pseudomonas maltophilia. Sch 34343 was quite stable to hydrolysis by beta-lactamases, including both penicillinases and cephalosporinases. However, Sch 34343 was slightly hydrolyzed by a new type of beta-lactamase (oxyiminocephalosporin beta-lactamase), as was imipenem. Sch 34343 was slightly hydrolyzed by renal dehydropeptidase 1 but was somewhat more stable than other carbapenems.

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