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Case Reports
. 2024 May 11;14(5):510.
doi: 10.3390/jpm14050510.

Double Primary Cancer of the Prostate and Urothelial Cancer: A Single Institution Experience

Affiliations
Case Reports

Double Primary Cancer of the Prostate and Urothelial Cancer: A Single Institution Experience

Senji Hoshi et al. J Pers Med. .

Abstract

Prostate cancer (PCa) ranks as the second most common cancer in Japanese males, while bladder cancer (BC) holds the tenth spot. Among double urological cancers, the incidence of synchronous or metachronous BC and PCa is the highest. Reports on upper urinary tract (UUT) urothelial cancer (UC) in PCa patients are limited. Here, we present three cases of metachronous PCa and BC, with subsequent diagnosis of ureteral and renal pelvic cancer during the course of the disease. In the follow-up of patients with urological cancers, it is important to be aware not only of the progression of the initial cancer but also the potential development of a second cancer.

Keywords: bladder cancer; prostate cancer; ureteral cancer; urothelial cancer.

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Conflict of interest statement

The authors have no conflicts of interest in the subject matter or materials discussed in this manuscript.

Figures

Figure 1
Figure 1
The treatment timeline.
Figure 2
Figure 2
Case 1. Coronal CT (A), and axial (B) and coronal (C) MRI images demonstrating a left ureteral tumor. Arrows indicate the tumor.
Figure 3
Figure 3
Case 2. Coronal (A) and axial (B) CT images demonstrating invasive left renal pelvic cancer.
Figure 4
Figure 4
Case 3. Dynamic CT images demonstrating a right ureteral tumor. Coronal view of renal cortex enhancement (A), and parenchymal (B) and excretion phases (C). Axial view (D). Arrows indicate the tumor.

References

    1. Coyte A., Morrison D.S., McLoone P. Second Primary Cancer Risk—The Impact of Applying Different Definitions of Multiple Primaries: Results from A Retrospective Population-Based Cancer Registry Study. BMC Cancer. 2014;14:272. doi: 10.1186/1471-2407-14-272. - DOI - PMC - PubMed
    1. Wang X., Zeng M., Ju X., Lin A., Zhou C., Shen J., Liu Z., Tang B., Cheng Q., Wang Y., et al. Correlation between Second and First Primary Cancer: Systematic Review and Meta-Analysis of 9 Million Cancer Patients. Br. J. Surg. 2024;111:znad377. doi: 10.1093/bjs/znad377. - DOI - PubMed
    1. Borzillo V., Scipilliti E., Pezzulla D., Serra M., Ametrano G., Quarto G., Perdona S., Rossetti S., Pignata S., Crispo A., et al. Stereotactic Body Radiotherapy with Cyberknife System for Low- and Intermediate-Risk Prostate Cancer: Clinical Outcomes and Toxicities Of CyPro Trial. Front. Oncol. 2023;13:1270498. doi: 10.3389/fonc.2023.1270498. - DOI - PMC - PubMed
    1. Clarke N., Wiechno P., Alekseev B., Sala N., Jones R., Kocak I., Chiuri V.E., Jassem J., Fléchon A., Redfern C., et al. Olaparib Combined with Abiraterone in Patients with Metastatic Castration-Resistant Prostate Cancer: A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trial. Lancet Oncol. 2018;19:975–986. doi: 10.1016/S1470-2045(18)30365-6. - DOI - PubMed
    1. Christopher J.D.W., Alyson L.M., Richard C., Sender H., Ronald T.K., Prakesh S.S., Cyril D., Steven A.N., Robert K.N. Second Malignancies after Radiotherapy for Prostate Cancer: Systematic Review and Meta-Analysis. BMJ. 2016;352:i851. - PMC - PubMed

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