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Review
. 2024 May 25;15(1):186.
doi: 10.1007/s12672-024-01053-6.

CEACAM6 expression and function in tumor biology: a comprehensive review

Dong Zhao #  1 , Fei Cai #  1   2 , Xuefei Liu  1 , Tingting Li  1 , Ershu Zhao  1 , Xinlong Wang  1 , Zhendong Zheng  3
Affiliations
Review

CEACAM6 expression and function in tumor biology: a comprehensive review

Dong Zhao et al. Discov Oncol. .

Abstract

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an immunoglobulin superfamily protein primarily expressed on epithelial surfaces and myeloid cells. It plays a significant role in cancer progression by inhibiting apoptosis, promoting drug resistance, and facilitating cancer cell invasion and metastasis. Overexpression of CEACAM6 has been observed in various cancers, including lung, breast, colorectal, and hepatocellular cancers, and is associated with poorer overall survival and disease-free survival. Its differential expression on tumor cell surfaces makes it a promising cancer marker. This review aims to provide a comprehensive summary of CEACAM6's role in different cancer types, its involvement in signaling pathways, and recent advancements in CEACAM6-targeted treatments.

Keywords: Biomarkers; CEACAM6; TME; Therapeutic target; Vaccine therapy.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
The mode of action of CEACAM6 in cancer
See this image and copyright information in PMC

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