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Review
. 2024 Sep;205(3):819-822.
doi: 10.1111/bjh.19564. Epub 2024 May 26.

Ras-associated autoimmune lymphoproliferative disorder

Affiliations
Review

Ras-associated autoimmune lymphoproliferative disorder

Kathleen E Sullivan et al. Br J Haematol. 2024 Sep.

Abstract

Distinguishing RALD from JMML can be difficult. This review discusses the clinical features, genetic aetiology and the treatments that are common and distinct between the two diagnoses.

Keywords: autoimmune disease; leukaemia; myeloid leukaemia; spleen.

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References

REFERENCES

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    1. Siano MA, Marchetti V, Pagano S, Di Candia F, Alessio M, De Brasi D, et al. Risk of autoimmune diseases in patients with RASopathies: systematic study of humoral and cellular immunity. Orphanet J Rare Dis. 2021;16(1):410.
    1. Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, et al. Clinical spectrum of Ras‐associated autoimmune leukoproliferative disorder (RALD). J Clin Immunol. 2021;41(1):51–58.
    1. Romano AA, Allanson JE, Dahlgren J, Gelb BD, Hall B, Pierpont ME, et al. Noonan syndrome: clinical features, diagnosis, and management guidelines. Pediatrics. 2010;126(4):746–759.

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