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Review
. 2024 May 10:15:1382977.
doi: 10.3389/fimmu.2024.1382977. eCollection 2024.

Application of CD38 monoclonal antibody in kidney disease

Zhiyi Chen  1   2 , Qianchun Xu  2   3 , Zhangfei Shou  2
Affiliations
Review

Application of CD38 monoclonal antibody in kidney disease

Zhiyi Chen et al. Front Immunol. .

Abstract

CD38 antigen is a glycoprotein that found on the surface of several immune cells, and this property makes its monoclonal antibodies have the effect of targeted elimination of immune cells. Therefore, the CD38 monoclonal antibody (such as daratumumab, Isatuximab) becomes a new treatment option for membranous nephropathy, lupus nephritis, renal transplantation, and other refractory kidney diseases. This review summarizes the application of CD38 monoclonal antibodies in different kidney diseases and highlights future prospects.

Keywords: CD38; daratumumab; kidney transplant; lupus nephritis; membranous nephropathy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of action of anti-CD38. formula image CD38;formula image Anti-CD38 (Daratumumab or lsatuximab); CDC, Complement Dependent Cytotoxicity; ADCC, Antibody Dependent Cell-mediated Cytotoxicity; ADCP, Antibody-Dependent Cellular Phagocytosis. (By Figdraw).
See this image and copyright information in PMC

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