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Review
. 2024 May 10:15:1395187.
doi: 10.3389/fimmu.2024.1395187. eCollection 2024.

Glycan-based scaffolds and nanoparticles as drug delivery system in cancer therapy

Henan Qin #  1 , Yibin Teng #  1 , Rui Dai  2 , Aman Wang  1 , Jiwei Liu  1
Affiliations
Review

Glycan-based scaffolds and nanoparticles as drug delivery system in cancer therapy

Henan Qin et al. Front Immunol. .

Abstract

Glycan-based scaffolds are unique in their high specificity, versatility, low immunogenicity, and ability to mimic natural carbohydrates, making them attractive candidates for use in cancer treatment. These scaffolds are made up of glycans, which are biopolymers with well biocompatibility in the human body that can be used for drug delivery. The versatility of glycan-based scaffolds allows for the modulation of drug activity and targeted delivery to specific cells or tissues, which increases the potency of drugs and reduces side effects. Despite their promise, there are still technical challenges in the design and production of glycan-based scaffolds, as well as limitations in their therapeutic efficacy and specificity.

Keywords: cancer; drug; glycan; glycosylation; scaffolds.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The common forms of glycan-based scaffolds and targeted delivery of drugs. Natural polymers utilized in drug delivery systems include chitosan, hyaluronic acid, dextran, and alginate. The uses of natural polymers to construct nanobiocomposites with anti-cancer agents is advantageous for targeted drug delivery and improving the antitumor efficacy.
Figure 2
Figure 2
Active targeting via nanocarriers for drug delivery against cancer cells. The ligands of nanocarriers can interact with overexpressed antigens or receptors in tumors. And nanocarriers then enters cancer cells through receptor-mediated endocytosis.
See this image and copyright information in PMC

References

    1. Koivusalo L, Kauppila M, Samanta S, Parihar VS, Ilmarinen T, Miettinen S, et al. Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma. Biomaterials. (2019) 225:119516. doi: 10.1016/j.biomaterials.2019.119516 - DOI - PubMed
    1. Kim W, Kim G. Collagen/bioceramic-based composite bioink to fabricate a porous 3d Hascs-laden structure for bone tissue regeneration. Biofabrication. (2019) 12:015007. doi: 10.1088/1758-5090/ab436d - DOI - PubMed
    1. Figueiredo T, Jing J, Jeacomine I, Olsson J, Gerfaud T, Boiteau JG, et al. Injectable self-healing hydrogels based on boronate ester formation between hyaluronic acid partners modified with benzoxaborin derivatives and saccharides. Biomacromolecules. (2020) 21:230–9. doi: 10.1021/acs.biomac.9b01128 - DOI - PubMed
    1. Huang S, Wu L, Li T, Xu D, Lin X, Wu C. Facile preparation of biomass lignin-based hydroxyethyl cellulose super-absorbent hydrogel for dye pollutant removal. Int J Biol Macromol. (2019) 137:939–47. doi: 10.1016/j.ijbiomac.2019.06.234 - DOI - PubMed
    1. Huang L, Du X, Fan S, Yang G, Shao H, Li D, et al. Bacterial cellulose nanofibers promote stress and fidelity of 3d-printed silk based hydrogel scaffold with hierarchical pores. Carbohydr Polym. (2019) 221:146–56. doi: 10.1016/j.carbpol.2019.05.080 - DOI - PubMed