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Case Reports
. 2024 May 22;12(6):e8829.
doi: 10.1002/ccr3.8829. eCollection 2024 Jun.

Generalized lichen planus pigmentosus and a new management approach

Farnaz Araghi  1 , Farideh Beyki  1 , Azadeh Rakhshan  1 , Hamideh Moravvej Farshi  1
Affiliations
Case Reports

Generalized lichen planus pigmentosus and a new management approach

Farnaz Araghi et al. Clin Case Rep. .

Abstract

Generalized lichen planus pigmentosus significantly improved with the daily administration of Tofacitinib at a dosage of 15 mg.

Keywords: generalized lichen planus pigmentosus; janus kinase inhibitors; lichen planus; tofacitinib.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
(A) The lesions were mostly violaceous and brown with fine scale, especially on the borders. (B) Exfoliation in the violaceous lesions was detected on the palmar regions of her both hands. (C) Telangiectasia was observed at the center of the lesions predominantly the ones on the face.
FIGURE 2
FIGURE 2
(A) Skin biopsy revealed acanthosis and mild superficial perivascular inflammation (H&E stain, x100). (B) The inflammation produces lichenoid interface reaction with presence of some Civatte bodies in basal layer. Upper dermal melanin incontinence and vascular ectasia are also noted (H&E stain, x400). (C) PAS staining shows mild thickening of basement membrane.
FIGURE 3
FIGURE 3
(A, B, C) In the next 4 month's follow‐up, her lesions improved significantly.
See this image and copyright information in PMC

References

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