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Review
. 2024 May-Jun;80(3):257-269.
doi: 10.1016/j.mjafi.2024.04.011. Epub 2024 Apr 26.

Review of facial acanthosis nigricans: Easy to diagnose and difficult to treat marker of hyperinsulinemia/metabolic syndrome

Shyam Verma  1 , Sunmeet Sandhu  2 , Narendra Kotwal  3 , Bhushan Madke  4 , Nidhi Yadav  5 , Biju Vasudevan  6
Affiliations
Review

Review of facial acanthosis nigricans: Easy to diagnose and difficult to treat marker of hyperinsulinemia/metabolic syndrome

Shyam Verma et al. Med J Armed Forces India. 2024 May-Jun.

Abstract

Facial acanthosis nigricans (FAN) is an increasingly discussed anatomical variation of acanthosis nigricans (AN). Its presentation as brown to black pigmentation with ill-defined blurred margins with varying degree of textural changes commonly over forehead, temporal, and malar regions of the face predominantly in dark-skinned individuals with a male predilection can be confused with other common facial melanoses. Its pathogenesis, clinical features, and management are in many ways similar to in the commonly described areas like neck and major flexural areas. Understanding of FAN has gained momentum in the past decade with studies highlighting its association with various metabolic abnormalities particularly insulin resistance and obesity. It is now being considered to be a cutaneous marker of metabolic syndrome. While there is uniformity in its clinical description, there appears to be scope for further in depth biochemical and histopathological studies to link the pigmentation, altered texture and microscopic changes in individuals presenting with FAN and hyperinsulinemia with or without other features of metabolic syndrome. It awaits a consensus on grading its severity and correlating it with histological features as patients often hesitate to be subjected to a biopsy of the face. This is a review of current literature pertaining to FAN. Newer clinical, dermoscopic, histopathological, and biochemical insights will help to understand this relatively new entity.

Keywords: Acanthosis nigricans; Facial acanthosis nigricans; HOMA-IR; Insulin resistance; Metformin.

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Conflict of interest statement

The authors have none to declare.

Figures

Fig. 1
Fig. 1
Dry rough thickening of skin in facial acanthosis nigricans.
Fig. 2
Fig. 2
Verrucous thickening in facial acanthosis nigricans.
Fig. 3
Fig. 3
C shaped pigmentation of facial acanthosis nigricans.
Fig. 4
Fig. 4
Eyelid involvement in facial acanthosis nigricans.
Fig. 5
Fig. 5
Perinasal involvement in Facial acanthosis nigricans.
Fig. 6
Fig. 6
Neck involvement in acanthosis nigricans.
Fig. 7
Fig. 7
Mild acanthosis nigricans.
Fig. 8
Fig. 8
Moderate acanthosis nigricans.
Fig. 9
Fig. 9
Severe acanthosis nigricans.
Fig. 10
Fig. 10
Dermoscopy of facial acanthosis nigricans depicting milder variant.
Fig. 11
Fig. 11
Dermoscopy of chronic acanthosis nigricans showing rhomboid island like features.
See this image and copyright information in PMC

References

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