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Case Reports
. 2024 Jan-Mar;28(1):125-129.
doi: 10.4103/jomfp.jomfp_500_22. Epub 2024 Apr 15.

Low-grade intraductal carcinoma in minor salivary glands: A case report and clinical insights

Alexandros Louizakis  1 , Dimitris Tatsis  1 , Stavroula Papadopoulou  1 , Konstantinos Vahtsevanos  1
Affiliations
Case Reports

Low-grade intraductal carcinoma in minor salivary glands: A case report and clinical insights

Alexandros Louizakis et al. J Oral Maxillofac Pathol. 2024 Jan-Mar.

Abstract

Rationale: Low-grade intraductal carcinoma (LG-IC), is a rare malignant tumour of the salivary glands which has a very good prognosis and must be differentiated from the other types of salivary gland malignant tumours, which have a totally different behaviour and a worse prognosis.

Patient concerns: A case is presented of a 52-year-old woman who was first diagnosed and treated in another clinic in 2019 for an LG-IC in the left submandibular gland space. Two years later, she was admitted to our department with a new lesion, this time in the upper jaw lip on the left side, which also turned out to be LG-IC.

Diagnosis: Magnetic resonance imaging and positron emission tomography-computed tomography were performed in order to diagnose and adequately stage the disease prior to the therapeutic intervention.

Outcomes: A 6-month follow-up reveals no sign of recurrence.

Takeaway lessons: Literature on this rare histopathological entity, as well as the differential diagnosis with the other malignant lesions of the salivary glands and the frequency of metastasis, were reviewed.

Keywords: Low-grade intraductal carcinoma; metastasis; minor salivary gland tumours; oral cancer; second primary cancer.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Magnetic resonance imaging scan. A circumcised lesion sized 2.5 × 1.7 cm2, presenting adjacent to the left submandibular gland. (a) STIR sequence axial plane, (b) STIR sequence coronal plane
Figure 2
Figure 2
Magnetic resonance imaging scan. A cystic lesion sized 1.3 × 1.1 cm2 is present in the left mucosal area of the upper lip. (a) STIR sequence, axial plane, (b) T2-weighted image, sagittal plane, (c): STIR sequence coronal plane. STIR: Short-TI Inversion Recovery
Figure 3
Figure 3
(a) Clinical presentation of the lesion of the upper lip shows an exophytic mass, well circumcised. (b) the excised specimen. (c) the resected area prior to surgical closure
Figure 4
Figure 4
(a) Papillary and focally cystic pattern (haematoxylin and eosin, ×40), (b) Intraductal growth. Distended duct with tufted papillary anastomosing proliferations (haematoxylin and eosin, ×40), (c) Well circumscribed and unencapsulated at low power (haematoxylin and eosin, ×100), (d) Small cuboidal cells with eosinophilic cytoplasm and small, oval nuclei with dispersed chromatin, inconspicuous nucleoli. Low-grade nuclear features. Mild nuclear pleomorphism (haematoxylin and eosin, ×200)
Figure 5
Figure 5
(a) Cytokeratin 7 (+) (×100) (b) Cytokeratin 8/18 (+) (×100) (c) Ki-67 proliferation marker 3% (×200), (d) Pathology image of the previous submandibular lesion present lymph node metastasis, similar to the upper lip lesion (haematoxylin and eosin, ×40)
Figure 6
Figure 6
Demonstration by immunohistochemistry of a myoepithelial layer (p63). (a) ×10, (b) ×10, (c) ×20
Figure 7
Figure 7
Demonstration by immunohistochemistry of a myoepithelial layer around cell nests (p63). (a) ×10, (b) ×10
See this image and copyright information in PMC

References

    1. Giovacchini F, Bensi C, Belli S, Laurenti ME, Mandarano M, Paradiso D, et al. Low-grade intraductal carcinoma of salivary glands:A systematic review of this rare entity. J Oral Biol Craniofacial Res. 2019;9:96–110. - PMC - PubMed
    1. Nishijima T, Yamamoto H, Nakano T, Hatanaka Y, Taguchi K, Masuda M, et al. Low-grade intraductal carcinoma (low-grade cribriform cystadenocarcinoma) with tumor-associated lymphoid proliferation of parotid gland. Pathol Res Pract. 2017;213:706–9. - PubMed
    1. Kuo YJ, Weinreb I, Perez-Ordonez B. Low-grade salivary duct carcinoma or low-grade intraductal carcinoma?Review of the literature. Head Neck Pathol. 2013;7(Suppl 1):59–67. - PMC - PubMed
    1. El-Naggar AK, Chan JCK, Grandis JR, Takata T, Slootweg PJ. In:WHO Classification of Tumours of the Oral Cavity. 4th ed. Lyon: IARC; 2017. WHO Classification of Head and Neck Tumours. Available from: https://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=70&c... .
    1. Palicelli A. Intraductal carcinomas of the salivary glands:Systematic review and classification of 93 published cases. APMIS. 2020;128:191–200. - PubMed

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