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Case Reports
. 2024 May 24;2024(5):rjae323.
doi: 10.1093/jscr/rjae323. eCollection 2024 May.

Primary epithelioid angiosarcoma of the mandibular gingiva: diagnostic pitfalls, about an unusual entity

Hafsa El Ouazzani  1   2 , Olaya Hamidi  2   3 , Alain Habimana  2   3 , Bouchra Dani  2   3 , M Boulaadas  2   3 , Fouad Zouaidia  2   4 , Nadia Cherradi  1   2
Affiliations
Case Reports

Primary epithelioid angiosarcoma of the mandibular gingiva: diagnostic pitfalls, about an unusual entity

Hafsa El Ouazzani et al. J Surg Case Rep. .

Abstract

Primary angiosarcoma of the oral cavity is a rare malignant vascular neoplasm variably recapitulating endothelial cells and is generally associated with a worse prognosis. The epithelioid subtype is even uncommon in this localization. To our knowledge, only seven cases of primary oral epithelioid angiosarcoma have been reported until 2021. This histopathological variant is characterized by solid and sheet-like growth patterns that may be misinterpreted as other lesions with epithelioid cells. Herein, we present a new case of primary epithelioid angiosarcoma of the mandibular gingiva to discuss histopathological differential diagnoses and potential diagnostic pitfalls.

Keywords: case report; differential diagnosis; epithelioid angiosarcoma; gingiva; histopathology.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
(a) Clinical image of an intraoral EA localized at the mandibular gingiva with extensive red-purple appearance; (b) orthopantomographic image showing resorption of the mandibular bone around the crown of the 44 and 46 teeth.
Figure 2
Figure 2
(a) Microphotography of EA showing a solid and sheet-like proliferation (star) under the squamous epithelium covering the gingival mucosa (arrow) (Hematoxylin–Eosin ×10); tumor cells show marked cellular pleomorphism with abundant eosinophilic cytoplasm (Hematoxylin–Eosin ×10); (c) the tumor exhibits a vasoformative architecture; at IHC, tumor cells express CD31 (d), ERG (e), CKAE1/AE3 (f), and CK7 (g).
See this image and copyright information in PMC

References

    1. Nelson BL. Angiosarcoma oral cavity. In: Diagnostic Pathology. Head and Neck, 3rd edn. Philadelphia/US: Elsevier, 2016, 482–3.
    1. Fanburg-Smith JC, Furlong MA, Childers EL. Oral and salivary gland angiosarcoma: a clinicopathologic study of 29 cases. Mod Pathol 2003;16:263–71. 10.1097/01.MP.0000056986.08999.FD. - DOI - PubMed
    1. Nagata M, Yoshitake Y, Nakayama H, et al. . Angiosarcoma of the oral cavity: a clinicopathological study and a review of the literature. Int J Oral Maxillofac Surg 2014;43:917–23. 10.1016/j.ijom.2014.02.008. - DOI - PubMed
    1. Sasaki M, Kumamoto H, Ooya K. An autopsy case of epitheliod angiosarcoma of the maxilla. Oral Med Pathol 1996;1:38–42. 10.3353/omp.1.38. - DOI
    1. Weiss SW, Antonescu CR, Deyrup AT. Angiosarcoma of soft tissue. In: WHO Classification of Tumors of Soft Tissue and Bone, 4th edn. Lyon (France): IARC Press, 2013, 156–8.

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