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. 2024 Apr 28;21(4):421-430.
doi: 10.26599/1671-5411.2024.04.003.

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

Jing Tan  1 , Jin Si  2 , Ke-Ling Xiao  2 , Ying-Hua Zhang  1 , Qi Hua  1 , Jing Li  2
Affiliations

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

Jing Tan et al. J Geriatr Cardiol. .

Abstract

Background: Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction (STEMI) are available.

Methods: We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months (interquartile range: 26-73 months) follow-up period were compared between patients with the low prealbumin level (< 170 mg/L) and those with the high prealbumin level (≥ 170 mg/L).

Results: A total of 114 patients (4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class III (9.9% vs. 4.4%, P = 0.034), cardiovascular death (8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events (19.2% vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level (< 170 mg/L) was an independent predictor of in-hospital major adverse cardiovascular events (odds ratio = 1.918, 95% CI: 1.250-2.942, P = 0.003). The cut-off value of prealbumin level for predicting in-hospital death was 170 mg/L (area under the curve = 0.703, 95% CI: 0.651-0.754, P < 0.001; sensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level (170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent results.

Conclusions: Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently associated with an increased risk of long-term cardiovascular mortality in STEMI patients.

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Figures

Figure 1
Figure 1
The receiver operating characteristic curve analysis for prealbumin and GRACE risk score for predicting in-hospital mortality in ST-segment elevation myocardial infarction patients.
Figure 2
Figure 2
Kaplan–Meier cumulative survival rate (A) and cardiovascular event-free survival rate (B), comparisons of ST-segment elevation myocardial infarction patients with the low prealbumin level (< 170 mg/L) and the high prealbumin level (≥ 170 mg/L) before propensity score matching.
Figure 3
Figure 3
Kaplan–Meier cumulative survival rate (A) and cardiovascular event-free survival rate (B), comparisons of ST-segment elevation myocardial infarction patients with the low prealbumin level (< 170 mg/L) and the high prealbumin level (≥ 170 mg/L) after propensity score matching.
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References

    1. Granger CB, Goldberg RJ, Dabbous O, et al Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345–2353. doi: 10.1001/archinte.163.19.2345. - DOI - PubMed
    1. Eagle KA, Lim MJ, Dabbous OH, et al A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA. 2004;291:2727–2733. doi: 10.1001/jama.291.22.2727. - DOI - PubMed
    1. Chen YH, Huang SS, Lin SJ TIMI and GRACE risk scores predict both short-term and long-term outcomes in Chinese patients with acute myocardial infarction. Acta Cardiol Sin. 2018;34:4–12. doi: 10.6515/ACS.201801_34(1).20170730B. - DOI - PMC - PubMed
    1. Kontos MC, Lanfear DE, Gosch K, et al Prognostic value of serial N-terminal pro-brain natriuretic peptide testing in patients with acute myocardial infarction. Am J Cardiol. 2017;120:181–185. doi: 10.1016/j.amjcard.2017.04.004. - DOI - PMC - PubMed
    1. Zamani P, Schwartz GG, Olsson AG, et al Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study. J Am Heart Assoc. 2013;2:e003103. doi: 10.1161/JAHA.112.003103. - DOI - PMC - PubMed

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