Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City
- PMID: 38801124
- PMCID: PMC11247679
- DOI: 10.1002/alz.13850
Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City
Abstract
Introduction: While Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care.
Methods: In 2023, the Alzheimer's Association hosted its eighth satellite symposium in Mexico, highlighting emerging dementia research, priorities, and challenges within LatAm.
Results: Significant initiatives in the region, including intracountry support, showcased their efforts in fostering national and international collaborations; genetic studies unveiled the unique genetic admixture in LatAm; researchers conducting emerging clinical trials discussed ongoing culturally specific interventions; and the urgent need to harmonize practices and studies, improve diagnosis and care, and use affordable biomarkers in the region was highlighted.
Discussion: The myriad of topics discussed at the 2023 AAIC satellite symposium highlighted the growing research efforts in LatAm, providing valuable insights into dementia biology, genetics, epidemiology, treatment, and care.
Keywords: Alzheimer's disease; Hispanics; Latin America; biomarkers; dementia; genetics.
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Conflict of interest statement
S. Mahinrad, C. E. Sexton, and M. C. Carrillo are full‐time employees of the Alzheimer's Association. A. L. Sosa reports receiving in the past 36 months consulting fees from Grupo Toscana; receiving payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or education events from Aphopharma, Biogen, Carnot, and Lundbeck; and participating in a data safety monitoring board or advisory board of Roche. S. M. D. Brucki reports receiving in the past 36 months consulting fees from Biogen and Roche; payment for lectures at Aché Pharmaceuticals and Novo Nordisk; and support from Novo Nordisk to attend meetings. L Crivelli reports receiving in the past 36 months reimbursement for travel expenses as a member of the Scientific Program Committee to attend AAIC Satellite Mexico 2023, AAIC Amsterdam 2023, and as part of the IMPACT‐AD fellowship from Alzheimer's Association and IMPACT‐AD. F. J. Lopera reports receiving in the past 36 months fees for consulting to Dr. Joseph Arboleda in the Alzheimer's Resistance program, receiving patent Antibody APOE3Ch, and participating on the advisory board of VIEW MIND. D. Acosta reports receiving in the past 36 months support for attending the 2023 AAIC Satellite Symposium in Mexico. J. A. Uribe reports receiving in the past 36 months payment or honoraria from Cajal Neuroscience and Regeneron and support for attending meetings from the University of California Santa Barbara and Rainwater Charitable Foundation. P. H. F. Bertolucci reports receiving in the past 36 months consulting fees from Novo Nordisk, Knight Laboratories, and Support‐Danone; payment from Novo Nordisk for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events; and support from Novo Nordisk for attending meetings. I. L. Calandri reports receiving in the past 36 months support from the Alzheimer's Association to attend AAIC Satellite Mexico 2023. M. C‐Olivas reports receiving in the past 36 months payment or honoraria from MDS for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events; support from National Institutes of Health (NIH) subcontract and ASAP/GP2/MJF for attending meetings; and serving on the MDS‐PAS Executive Committee and as regional mentor for GBHI Fellowship and President of Rare Disorders National Board. N. Custodio reports receiving support to attend the AAIC Satellite Symposium, Mexico 2023. A. Damian reports receiving support to attend the AAIC Satellite Symposium Mexico 2023. L. C. de Souza reports receiving in the past 36 months payment for the development of continuing medical education material and participation as a speaker in symposia sponsored by Biogen and Abbott and payment for serving on the advisory board for Biogen and Lilly. M. García reports receiving financial support from TELL SA and receiving support from Alzheimer's Association to attend AAIC Satellite Mexico 2023. M. M. Gonzales reports having personal stock in AbbVie. L. T. Grinberg reports receiving in the past 36 months consulting fees from Guidepoint Global Inc.; receiving payment or honoraria from Medscape Inc. and Celdare Medical for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events; receiving support for attending meetings and/or travel from the Alzheimer's Association and BrightFocus Foundation; and serving in leadership or fiduciary roles in Global Brain Health Institute. M. Z. I‐M. reports receiving in the past 36 months support for attending meetings and/or travel from the Alzheimer's Association and Global Brain Health Institute. J. M. Leon‐Salas reports receiving in the past 36 months support for attending meetings and/or travel from the Alzheimer's Association. B. L. Miller reports receiving in the past 36 months payments for royalties or licenses from Cambridge University Press, Elsevier, Inc., Guilford Publications, Inc., Johns Hopkins Press, Oxford University Press, and Taylor & Francis Group; consulting fees from Massachusetts General Hospital Alzheimer's Disease Research Center (ADRC) Scientific Advisory Board (SAB), Stanford University ADRC SAB, University of Washington ADRC SAB, and Genworth Medical Advisory Board; receiving payments from the Institute for Lifelong Learning, Global Summit on Neurodegenerative Diseases, Korean Dementia Society, Massachusetts General Hospital, dementia course, National MS Society, Don Paty Lectureship, Ochsner Neuroscience Institute, Providence Saint Joseph Medical Center, Taipei Medical University, Dementia Center, UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Los Angeles (UCLA) Grand Round, University of Texas, and Center for Brain Health for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events; receiving support for attending meetings and/or travel from the Association for Frontotemporal Degeneration (AFTD) Education Symposium, St. Louis, MO, Milken Institute FTD Scientific Retreat, Los Angeles, CA, California Institute of the Arts, Los Angeles, CA, and UCLA; serving on a Data Safety Monitoring Board or Advisory Board of Arizona Alzheimer's Consortium, Association for Frontotemporal Degeneration, The Buck Institute for Research on Aging, Cure ALS, The John Douglas French Alzheimer's Foundation, Fundación Centro de Investigación Enfermedades Neurológicas, Madrid, Spain, Genworth, The Larry L. Hillblom Foundation, Massachusetts General Hospital ADRC, National Institute for Health Research Cambridge Biomedical Research Center and its subunit, the Biomedical Research Unit in Dementia, Stanford University ADRC, University of Southern California P01 Urban Air Pollution and Alzheimer's Disease: Risk, Heterogeneity, and Mechanisms, and University of Washington ADR; having a leadership or fiduciary role in the Bluefield Project to Cure FTD, Global Brain Health Institute, Institute for Neurodegenerative Diseases and Tau Consortium of the Rainwater Charitable Fdtn. L. Naci reports receiving in the past 36 months support from the Global Brain Health Institute for attending meetings and/or travel. M. A. Parra reports receiving in the past 36 months consulting fees from ViewMind. E. D. P. F. Resende reports receiving consulting fees from United Medical Ltda in 2021, payment or honoraria from Proneuro, NovoNordisk, and Roche for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events; receiving support for attending meetings and/or travel from the Alzheimer's Association; serving as the deputy chair of the Scientific Department for Behavioral Neurology and Aging at the Brazilian Academy of Neurology. J. M. Ringman reports receiving in the past 36 months consulting fees from Eisai Pharmaceuticals, payments from PriMed CME/CE organization for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events; support from the Alzheimer's Association to attend the AAIC Satellite Mexico 2023; and doses of flortaucipir for research from Avid Pharmaceuticals. G. Sevlever reports receiving support for attending meetings and/or travel from Fleni, Buenos Aires, Argentina. A. Slachevsky reports receiving support from the Alzheimer's Association and GBHI for attending meetings and/or travel and having a leadership or fiduciary role on the board of Global Brain Health Institute. C. K. Suemoto reports receiving a travel fellowship from the Alzheimer's Association to attend the 2023 AAIC Satellite Symposium and serving on the ISTAART advisory council and in Brazilian Society of Geriatrics and Gerontology. V. Valcour reports receiving payment or honoraria from IAS‐USA for providing CME; and support from the Atlantic Philanthropies for attending meetings and/or travel. M. S. Yassuda reports payment or honoraria from Supera – Brazilian Company and Institute of Neurology – BRAIN Congress in Brazil for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events amd support from Brazilian National Council for Scientific and Technological Development and the Alzheimer´s Association to attend AAIC in Mexico.
The remaining authors have nothing to declare. Author disclosures are available in the supporting information.
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Grants and funding
- SG-20-725707/AG/NIA NIH HHS/United States
- R01 AG062588/AG/NIA NIH HHS/United States
- LatAm FINGERS
- Rainwater Charitable Foundation and Center for Alzheimer's Disease and Related Dementias
- P30 AG062422/AG/NIA NIH HHS/United States
- P01 AG019724/AG/NIA NIH HHS/United States
- R01 AG057234/AG/NIA NIH HHS/United States
- R56 AG069118/AG/NIA NIH HHS/United States
- R01 AG062007/AG/NIA NIH HHS/United States
- Rainwater Charitable Foundation - Tau Consortium, and Global Brain Health Institute
- R01 AG075775/AG/NIA NIH HHS/United States
- R01 NS114382/NS/NINDS NIH HHS/United States
- ALZ/Alzheimer's Association/United States
- R01 AG052496/AG/NIA NIH HHS/United States
- NIH
- R01 AG064778/AG/NIA NIH HHS/United States
- 308606/2022-1/the Brazilian National Council for Scientific and Technological Development (CNPq)
- P30 AG066530/AG/NIA NIH HHS/United States
- R35 AG072362/AG/NIA NIH HHS/United States
- the Alzheimer's Association and FAPESP
- UH3 NS100614/NS/NINDS NIH HHS/United States
- K01 AG073526/AG/NIA NIH HHS/United States
- R01 AG070883/AG/NIA NIH HHS/United States
- R01 AG062562/AG/NIA NIH HHS/United States