Microbiologist in the Clinic: Postmenopausal Woman with Chronic OAB and Positive Urine Culture
- PMID: 38801554
- DOI: 10.1007/s00192-024-05819-y
Microbiologist in the Clinic: Postmenopausal Woman with Chronic OAB and Positive Urine Culture
Abstract
In this second episode of the Microbiologist in the Clinic series, clinicians and laboratory scientists share their perspectives about a 75-year-old woman who was diagnosed with asymptomatic bacteriuria based on positive urine cultures. The patient and her GP are concerned about this laboratory finding as the patient will become immunosuppressed with planned chemotherapy. The patient has had an overactive bladder (OAB) for approximately 20 years, with good control of her urinary urgency and frequency (no incontinence) with a stable dose of OAB medication. The challenges of this clinical presentation are discussed, with evidence for evaluation and treatment.
Keywords: Antibiotics; Lower urinary tract symptoms; Microbiome; Overactive bladder; Pyuria; UTI; Urobiome; Women’s health.
© 2024. The International Urogynecological Association.
Similar articles
-
Microbiologist in the clinic: coitally related symptoms with negative urine cultures.Int Urogynecol J. 2023 Nov;34(11):2701-2704. doi: 10.1007/s00192-023-05662-7. Epub 2023 Oct 14. Int Urogynecol J. 2023. PMID: 37837460
-
Microbiologist in the Clinic: Antibiotic Dependent in her 30 s.Int Urogynecol J. 2025 Apr;36(4):783-788. doi: 10.1007/s00192-025-06142-w. Epub 2025 Apr 12. Int Urogynecol J. 2025. PMID: 40220054
-
Recurrent Urinary Tract Infections in Females and the Overlap with Overactive Bladder.Curr Urol Rep. 2018 Sep 13;19(11):94. doi: 10.1007/s11934-018-0839-3. Curr Urol Rep. 2018. PMID: 30215140 Review.
-
Vaginal estrogen therapy is associated with increased Lactobacillus in the urine of postmenopausal women with overactive bladder symptoms.Am J Obstet Gynecol. 2020 Nov;223(5):727.e1-727.e11. doi: 10.1016/j.ajog.2020.08.006. Epub 2020 Aug 11. Am J Obstet Gynecol. 2020. PMID: 32791124 Free PMC article.
-
Urinary tract infections in older women: a clinical review.JAMA. 2014 Feb 26;311(8):844-54. doi: 10.1001/jama.2014.303. JAMA. 2014. PMID: 24570248 Free PMC article. Review.
References
-
- Abraham SN, Miao Y. The nature of immune responses to urinary tract infections. Nat Rev Immunol. 2015;15(10):655–63. https://doi.org/10.1038/nri3887 . - DOI - PubMed - PMC
-
- Falagas ME, Kotsantis IK, Vouloumanou EK, Rafailidis PI. Antibiotics versus placebo in the treatment of women with uncomplicated cystitis: a meta-analysis of randomized controlled trials. J Infect. 2009;58(2):91–102. https://doi.org/10.1016/j.jinf.2008.12.009 . - DOI - PubMed
-
- Nielsen KL, Dynesen P, Larsen P, Frimodt-Møller N. Faecal Escherichia coli from patients with E. coli urinary tract infection and healthy controls who have never had a urinary tract infection. J Med Microbiol. 2014;63(4):582–9. https://doi.org/10.1099/jmm.0.068783-0 . - DOI - PubMed
-
- Hayes BW, Abraham SN. Innate immune responses to bladder infection. Microbiol Spectr. 2016;4(6). https://doi.org/10.1128/microbiolspec.uti-0024-2016 .
-
- Sarkissian Milner CA, Alteri CJ, Mobley HLT. UTI patients have pre-existing antigen-specific antibody titers against UTI vaccine antigens. Vaccine. 2019;37(35):4937–46. https://doi.org/10.1016/j.vaccine.2019.07.031 . - DOI
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical