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. 2024 Aug;39(4):694-698.
doi: 10.1016/j.virs.2024.05.008. Epub 2024 May 25.

Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai, China, 2022

Jiayu Wang  1 , Wencheng Wu  1 , Wei Wang  1 , Jingyi Zhang  1 , Jianwei Xiao  2 , Mingyi Cai  3 , Jiaying Guo  4 , Run Li  1 , Shuangli Zhu  5 , Wanju Zhang  1 , Min Chen  1 , Zheng Teng  6
Affiliations

Seroprevalence of neutralizing antibodies against HFMD associated enteroviruses among healthy individuals in Shanghai, China, 2022

Jiayu Wang et al. Virol Sin. 2024 Aug.

Abstract

  1. •

    The first report of serological characteristics of HFMD associated enteroviruses in Shanghai after the COVID-19 epidemic.

  2. •

    The seroprevalence of protective NtAbs against Coxsackieviruses was low within the susceptible population of HFMD.

  3. •

    The presence of a silent outbreak and circulation of CVA4 was confirmed among elderly individuals.

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Figures

Fig. 1
Fig. 1
Serological and etiological distributions of HFMD associated enteroviruses in Shanghai. A–C Seroprevalence of NtAbs against five enteroviruses in healthy individuals among different age groups. The Y-axis represents the seropositive rate of NtAb against the indicated enteroviruses. The X-axis represents different age groups. A The overall seroprevalence of enteroviruses NtAbs (NtAb titers ≥ 8). B Seroprevalence of protective NtAbs (NtAb titers ≥ 16). C Seroprevalence of high level NtAbs (NtAb titers ≥ 256). D–H Titer distributions of NtAbs against the five enteroviruses, EV-A71 (D), CVA16 (E), CVA6 (F), CVA10 (G) and CVA4 (H) in healthy individuals among different age groups. The X-axis represents different age groups. The Y-axis represents NtAb titers against the five enteroviruses. The box plot shows the minimum, first quartile, median, third quartile and maximum titer levels. I Co-existence of NtAbs against the five enteroviruses in healthy individuals. The X-axis represents the number of seropositive-NtAbs healthy individuals carried. The Y-axis represents the seropositive rate of NtAbs. J Yearly distribution of HFMD associated enteroviruses. The yearly detection rates of CVA16 ranged from 4.41% to 22.20% during 2020–2022. K Monthly distribution of enterovirus serotypes in HFMD cases in Shanghai during 2020–2023.
figs1
Fig. S1
Phylogenetic analysis of enterovirus isolates used in current study based on complete VP1 sequences.
See this image and copyright information in PMC

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