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Review
. 2024 May 15;26(5):523-528.
doi: 10.7499/j.issn.1008-8830.2311148.

[Application of near-infrared spectroscopy in the early identification of neonatal gastrointestinal diseases]

[Article in Chinese]
Alimujiang Gulizuohere  1 , Rejiafu Nuerya  1
Affiliations
Review

[Application of near-infrared spectroscopy in the early identification of neonatal gastrointestinal diseases]

[Article in Chinese]
Alimujiang Gulizuohere et al. Zhongguo Dang Dai Er Ke Za Zhi. .

Abstract
in English, Chinese

Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal diseases in neonatal intensive care units, characterized by rapid progression and a high mortality rate. Local intestinal ischemia and hypoxia are significant contributors to NEC. Feeding intolerance (FI), which refers to a range of gastrointestinal manifestations arising from the inability to tolerate enteral nutrition, is one of the most common clinical issues in neonates, and preventing and treating FI is crucial for improving neonatal survival rates. Near-infrared spectroscopy is a clinical tool that can be used at the bedside to monitor regional oxygen saturation. It is non-invasive, reliable, and sustainable, and its feasibility and safety in assessing intestinal blood circulation have been validated. Early identification of intestinal ischemia and differentiation of FI from precursor symptoms of NEC, as well as predicting the occurrence of NEC, are extremely important for reducing intestinal injury and adverse long-term outcomes. In recent years, there has been new research progress related to the monitoring of intestinal tissue oxygen saturation and cerebral oxygen saturation for the early identification of FI and precursor symptoms of NEC, and this article provides a review of these developments.

新生儿坏死性小肠结肠炎（necrotizing enterocolitis, NEC）是新生儿重症监护病房最常见的胃肠道疾病之一，进展迅速，病死率较高，肠道局部缺血缺氧是导致NEC的重要原因。喂养不耐受（feeding intolerance, FI）指不能耐受肠内营养而出现的一系列胃肠道表现，是目前新生儿最常见的临床问题之一，防治FI对提高新生儿存活率意义重大。近红外光谱是一种可用于床旁监测区域氧饱和度的临床工具，具有无创、可靠、可持续等优点，在测定肠道血液循环状况方面其可行性和安全性也得到了验证。早期识别肠道缺血并鉴别FI与NEC的前驱症状，预测NEC的发生，对减少肠道损伤及远期不良预后极为重要。近年来，对监测肠道组织氧饱和度和脑组织氧饱和度以早期识别FI与NEC的前驱症状相关临床事件有了新的研究进展。该文对近年来近红外光谱在监测新生儿NEC及FI区域血氧方面的应用进展及相关成果进行综述。.

Keywords: Feeding intolerance; Near infrared spectroscopy; Necrotizing enterocolitis; Neonate; Regional oxygen saturation.

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Conflict of interest statement

所有作者不存在利益冲突。

References

    1. 邵肖梅, 叶鸿瑁, 丘小汕. 实用新生儿学[M]. 5版. 北京: 人民卫生出版社, 2019: 632-639.
    1. 李佳美, 梁会营. 近10年早产儿坏死性小肠结肠炎文献计量分析[J]. 中国现代医生, 2022, 60(31): 73-77.
    1. Duchon J, Barbian ME, Denning PW. Necrotizing enterocolitis[J]. Clin Perinatol, 2021, 48(2): 229-250. DOI: 10.1016/j.clp.2021.03.002. - DOI - PubMed
    1. Mishra V, Cuna A, Singh R, et al. . Imaging for diagnosis and assessment of necrotizing enterocolitis[J]. Newborn (Clarksville), 2022, 1(1): 182-189. DOI: 10.5005/jp-journals-11002-0002. - DOI - PMC - PubMed
    1. Hong L, Huang Y, Jiang S, et al. . Postnatal dynamics and clinical associations of fecal calprotectin in very preterm infants: implications for necrotizing enterocolitis and feeding intolerance[J]. Clin Transl Gastroenterol, 2023, 14(8): e00604. DOI: 10.14309/ctg.0000000000000604. - DOI - PMC - PubMed

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