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. 2024 Aug;54(8):e2350851.
doi: 10.1002/eji.202350851. Epub 2024 May 27.

Sex-specific impact of psychosocial stress on hematopoiesis and blood leukocytes

Bastien Dolfi  1 , Alexandre Gallerand  1 , Zakariya Caillot  1 , Alexia Castiglione  1 , Fairouz N Zair  1 , Lorlana Leporati  1 , Margaux Giacchero  1 , Eloïse Goës  1 , Axelle Strazzulla  1 , David Dombrowicz  2 , Rodolphe R Guinamard  1 , Adeline Bertola  1 , Stoyan Ivanov  1
Affiliations
Free article

Sex-specific impact of psychosocial stress on hematopoiesis and blood leukocytes

Bastien Dolfi et al. Eur J Immunol. 2024 Aug.
Free article

Abstract

Stress exposure has been shown to modulate innate and adaptive immune responses. Indeed, stress favors myelopoiesis and monocyte generation and contributes to cardiovascular disease development. As sex hormones regulate innate and adaptive immune responses, we decided to investigate whether stress exposure leads to a different immune response in female and male mice. Our data demonstrated that psychosocial stressinduced neutrophilia in male, but not female mice. Importantly, we identified that B-cell numbers were reduced in female, but not male mice upon exposure to stress. Thus, our study revealed that the stress-induced immune alterations are sex-dependent, and this is an important feature to consider for future investigations.

Keywords: B cells; Neutrophils; Sexual dimorphism; Stress.

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References

    1. Heidt, T., Sager, H. B., Courties, G., Dutta, P., Iwamoto, Y., Zaltsman, A., von Zur Muhlen, C. et al., Chronic variable stress activates hematopoietic stem cells. Nat. Med. 2014. 20: 754–758.
    1. Barrett, T. J., Corr, E. M., van Solingen, C., Schlamp, F., Brown, E. J., Koelwyn, G. J., Lee, A. H. et al., Chronic stress primes innate immune responses in mice and humans. Cell Rep. 2021. 36: 109595.
    1. Poller, W. C., Downey, J., Mooslechner, A. A., Khan, N., Li, L., Chan, C. T., McAlpine, C. S. et al., Brain motor and fear circuits regulate leukocytes during acute stress. Nature 2022. 607: 578–584.
    1. Dunn, S. E., Perry, W. A. and Klein, S. L., Mechanisms and consequences of sex differences in immune responses. Nat. Rev. Nephrol. 2024. 20: 37–55.
    1. Hoffmann, J. P., Liu, J. A., Seddu, K. and Klein, S. L., Sex hormone signaling and regulation of immune function. Immunity. 2023. 56: 2472–2491.