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Review
. 2024 May 13:15:1415147.
doi: 10.3389/fphar.2024.1415147. eCollection 2024.

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Huina Guo  1   2 , YiChen Lou  1   2   3 , Xiaofang Hou  1   2   3 , Qi Han  1   2 , Yujia Guo  1   2 , Zhongxun Li  1   2 , Xiaoya Guan  1   2 , Hongliang Liu  1   2   4   5 , Chunming Zhang  1   2   4
Affiliations
Review

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Huina Guo et al. Front Pharmacol. .

Abstract

As a traditional Chinese medicinal herb with a long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes the research progress of CP in the medical field in the past 5 years. By searching and analyzing the literature, and combining with Cytoscape software, we comprehensively examined the role and mechanism of action of CP in individual application, combination drug application, and the role and mechanism of action of codonopsis pilosula's active ingredients in a variety of diseases. It also analyzes the medicinal use of CP and its application value in medicine. This review found that CP mainly manifests important roles in several diseases, such as cardiovascular system, nervous system, digestive system, immune system, etc., and regulates the development of many diseases mainly through the mechanisms of inflammation regulation, oxidative stress, immunomodulation and apoptosis. Its rich pharmacological activities and diverse medicinal effects endow CP with broad prospects and application values. This review provides valuable reference and guidance for the further development of CP in traditional Chinese medicine.

Keywords: active ingredients; codonopsis pilosula (CP); combination drugs; cytoscape; diseases.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Article statey and analysis flowchart.
FIGURE 2
FIGURE 2
Targets of CP alone application in disease. Red represents CP. Blue represents disease. Orange represents targets.
FIGURE 3
FIGURE 3
Targets of CP combination drug in disease. Blue represents CP. Orange represents disease. Azure blue represents party ginseng combined with drugs. Pink represents targets.
FIGURE 4
FIGURE 4
Targets of CPPs in disease. Red represents CP. Blue represents the type of CPPs. Orange represents disease. Pink represents targets.
FIGURE 5
FIGURE 5
In addition to CPPs, targets of other active ingredients of CP in disease. Red represents CP. Blue represents the active ingredient of CP. Pink represents disease. Orange represents targets.
FIGURE 6
FIGURE 6
Diseases associated with the role of CP.
FIGURE 7
FIGURE 7
Diagram of the mechanism of CP action.
See this image and copyright information in PMC

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References

    1. Bai R., Cui F., Li W., Wang Y., Wang Z., Gao Y., et al. (2022). Codonopsis pilosula oligosaccharides modulate the gut microbiota and change serum metabolomic profiles in high-fat diet-induced obese mice. Food Funct. 13, 8143–8157. 10.1039/d2fo01119k - DOI - PubMed
    1. Bai R.-B., Zhang Y.-J., Fan J.-M., Jia X.-S., Li D., Wang Y.-P., et al. (2020). Immune-enhancement effects of oligosaccharides from Codonopsis pilosula on cyclophosphamide induced immunosuppression in mice. Food Funct. 11, 3306–3315. 10.1039/c9fo02969a - DOI - PubMed
    1. Bailly C. (2021). Anticancer properties of lobetyolin, an essential component of radix codonopsis (dangshen). Nat. Prod. Bioprospect 11, 143–153. 10.1007/s13659-020-00283-9 - DOI - PMC - PubMed
    1. Cao L., Du C., Zhai X., Li J., Meng J., Shao Y., et al. (2022). Codonopsis pilosula polysaccharide improved spleen deficiency in mice by modulating gut microbiota and energy related metabolisms. Front. Pharmacol. 13, 862763. 10.3389/fphar.2022.862763 - DOI - PMC - PubMed
    1. Cao M., Yu C., Yao Z., Gao X., Wu S. (2019a). Atractylodesin III maintains mitochondrial function and inhibits caspase-3 activity to reverse apoptosis of cardiomyocytes in AMI rats. Int. J. Clin. Exp. Pathol. 12, 198–204. - PMC - PubMed