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Case Reports
. 2024 Apr 27;16(4):e59137.
doi: 10.7759/cureus.59137. eCollection 2024 Apr.

Appendiceal Signet Ring Cell Carcinoma Presenting As Acute Appendicitis: A Case Report

Emily A Ina  1 , Alexandria Sobczak  1 , Konrad Drzymalski  1 , Alejandro Biglione  2
Affiliations
Case Reports

Appendiceal Signet Ring Cell Carcinoma Presenting As Acute Appendicitis: A Case Report

Emily A Ina et al. Cureus. .

Abstract

Appendiceal signet ring cell carcinoma is an exceedingly rare neoplasm which makes up only 4% of carcinomas of the appendix. It is a rare cause of abdominal pain which can mimic acute appendicitis. This case reports a 77-year-old female who presented to the emergency room with a complaint of right lower quadrant abdominal pain. After exploratory laparoscopy and histopathological studies, the patient was found to have peritoneal carcinomatosis and appendiceal signet ring cell carcinoma. This diagnosis unfortunately carries a relatively poor prognosis due to its aggressive nature. This study discusses the etiology, prevalence, clinical findings, and treatment of a rare cause of abdominal pain. This report sheds light on the importance of early detection and treatment of appendiceal signet ring cell carcinoma.

Keywords: appendiceal signet ring cell carcinoma; exploratory laparoscopy; gastrointestinal tumor; mimicker of acute appendicitis; rare neoplasm.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Abdominal T1-weighted axial view MRI without contrast (A) and T2-weighted axial view MRI with contrast (B).
Appendiceal and ileocecal thickening with abdominal and pelvic ascites, peritoneal thickening, and omental nodularity (arrows).
Figure 2
Figure 2. Abdominal T2-weighted coronal view image with contrast.
Image demonstrating appendiceal and peritoneal thickening and nodularity concerning perforated appendicitis with peritonitis versus appendix malignancy with carcinomatosis (arrows).
Figure 3
Figure 3. Intraoperative imaging of carcinomatosis of the abdominal wall.
See this image and copyright information in PMC

References

    1. Rising incidence of appendiceal neoplasms over time: does pathological handling of appendectomy specimens play a role? Bahmad HF, Aljamal AA, Alvarez Moreno JC, Salami A, Bao P, Alghamdi S, Poppiti RJ. Ann Diagn Pathol. 2021;52 - PubMed
    1. Rare case of appendiceal signet-ring cell carcinoma mimicking advanced ovarian cancer. Yang IF, Huang SH, Huang LW. J Cancer Res Pract. 2022;9:104–107.
    1. An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: III. expressions of EMA, CEA, CA19-9, CDX-2, p53, Ki-67 antigen, TTF-1, vimentin, and p63 in normal mucosa and in 42 cases. Terada T. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606852/pdf/ijcep0006-0630.pdf. Int J Clin Exp Pathol. 2013;6:630–638. - PMC - PubMed
    1. Osueni A, Chowdhury YS. StatPearls [Internet] Treasure Island, FL: StatPearls Publishing; 2023. Appendix cancer.
    1. Types of appendiceal cancer. [ Jan; 2024 ]. https://www.mskcc.org/cancer-care/types/appendiceal/diagnosis/types https://www.mskcc.org/cancer-care/types/appendiceal/diagnosis/types

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