Methodological considerations in meta-analysis: evaluating RCTs, NRS, and crossover trials for electrical impedance tomography in PEEP titration

Nickjaree Songsangvorn^{1

2}, Arthur S Slutsky^{1

3}, Karen E A Burns^{4

5}, Haibo Zhang^{6

7

8

9}

Affiliations

¹ Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
² Department of Critical Care Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
³ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
⁴ Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada. karen.burns@unityhealth.to.
⁵ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. karen.burns@unityhealth.to.
⁶ Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.
⁷ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.
⁸ Department of Physiology, University of Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.
⁹ Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.

Nickjaree Songsangvorn et al. Intensive Care Med. 2024 Jul.

. 2024 Jul;50(7):1188-1189.

doi: 10.1007/s00134-024-07462-z. Epub 2024 May 28.

Nickjaree Songsangvorn^{1

2}, Arthur S Slutsky^{1

3}, Karen E A Burns^{4

5}, Haibo Zhang^{6

7

8

9}

¹ Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
² Department of Critical Care Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
³ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
⁴ Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada. karen.burns@unityhealth.to.
⁵ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. karen.burns@unityhealth.to.
⁶ Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.
⁷ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.
⁸ Department of Physiology, University of Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.
⁹ Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. haibo.zhang@unityhealth.to.

No abstract available

References

1. Gu W-J (2024) Concern for meta-analysis combining randomized parallel and cross-over trials. Intensive Care Med. https://doi.org/10.1007/s00134-024-07426-3 - DOI - PubMed
1. Songsangvorn N, Xu Y, Lu C, Rotstein O, Brochard L, Slutsky AS et al (2024) Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. https://doi.org/10.1007/s00134-024-07362-2 - DOI - PubMed - PMC
1. Jimenez JV, Munroe E, Weirauch AJ, Fiorino K, Culter CA, Nelson K et al (2023) Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial. Crit Care. https://doi.org/10.1186/s13054-023-04315-x - DOI - PubMed - PMC
1. Higgins JP, Li T, Sterne J (2021) Revised cochrane risk of bias tool for randomized trials (RoB 2) additional considerations for crossover trials. https://www.riskofbias.info/welcome/rob-2-0-tool/rob-2-for-crossover-trials . Accessed 9 May 2023
1. Lathyris DN, Trikalinos TA, Ioannidis JP (2007) Evidence from crossover trials: empirical evaluation and comparison against parallel arm trials. Int J Epidemiol 36(2):422–430 - DOI - PubMed