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Review
. 2024 Jul;26(7):289-304.
doi: 10.1007/s11883-024-01206-6. Epub 2024 May 28.

The Role of Bacterial Extracellular Membrane Nanovesicles in Atherosclerosis: Unraveling a Potential Trigger

Konstantin A Lusta  1 , Volha I Summerhill  2 , Victoria A Khotina  1 , Vasily N Sukhorukov  1 , Victor Y Glanz  1 , Alexander N Orekhov  3   4
Affiliations
Review

The Role of Bacterial Extracellular Membrane Nanovesicles in Atherosclerosis: Unraveling a Potential Trigger

Konstantin A Lusta et al. Curr Atheroscler Rep. 2024 Jul.

Abstract

Purpose of review: In this review, we explore the intriguing and evolving connections between bacterial extracellular membrane nanovesicles (BEMNs) and atherosclerosis development, highlighting the evidence on molecular mechanisms by which BEMNs can promote the athero-inflammatory process that is central to the progression of atherosclerosis.

Recent findings: Atherosclerosis is a chronic inflammatory disease primarily driven by metabolic and lifestyle factors; however, some studies have suggested that bacterial infections may contribute to the development of both atherogenesis and inflammation in atherosclerotic lesions. In particular, the participation of BEMNs in atherosclerosis pathogenesis has attracted special attention. We provide some general insights into how the immune system responds to potential threats such as BEMNs during the development of atherosclerosis. A comprehensive understanding of contribution of BEMNs to atherosclerosis pathogenesis may lead to the development of targeted interventions for the prevention and treatment of the disease.

Keywords: Atherogenesis; Atherosclerosis; Bacterial extracellular membrane nanovesicles; Cardiovascular diseases; Immune response; Inflammation.

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