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Editorial
. 2024 May 28;149(22):1749-1751.
doi: 10.1161/CIRCULATIONAHA.124.069379. Epub 2024 May 28.

Extracellular Vesicles: Bridging the Heart and Tumor in Reverse Cardio-Oncology

Alexandra A C Newman  1 , Richard Von Itter  1 , Kathryn J Moore  1   2
Affiliations
Editorial

Extracellular Vesicles: Bridging the Heart and Tumor in Reverse Cardio-Oncology

Alexandra A C Newman et al. Circulation. .
No abstract available

Keywords: Editorials; cancer; cardio-oncology; cardiovascular disease; cytokines; extracellular vesicles.

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Conflict of interest statement

Disclosures None.

Figures

Figure 1:
Figure 1:. Cardiac secreted extracellular vesicles facilitate detrimental cross-disease communication between cardiovascular disease and cancer.
Following myocardial infarction, cardiac mesenchymal stromal cells (cMSCs) secrete small extracellular vesicles (sEVs) packaged with biologically active factors including pro-tumorigenic miRNAs, proteins, and cytokines. Uptake of sEVs by lung tumor cells heightens their cellular fitness, while uptake by distal tissues predisposes to metastatic tumor cell seeding. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth.
    Caller T, Rotem I, Shaihov-Teper O, Lendengolts D, Schary Y, Shai R, Glick-Saar E, Dominissini D, Motiei M, Katzir I, Popovtzer R, Nahmoud M, Boomgarden A, D'Souza-Schorey C, Naftali-Shani N, Leor J. Caller T, et al. Circulation. 2024 May 28;149(22):1729-1748. doi: 10.1161/CIRCULATIONAHA.123.066911. Epub 2024 Mar 15. Circulation. 2024. PMID: 38487879 Free PMC article.

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