Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep;1879(5):189123.
doi: 10.1016/j.bbcan.2024.189123. Epub 2024 May 26.

Epigenetic changes associated with Bacillus Calmette-Guerin (BCG) treatment in bladder cancer

Lucy C Picard  1 , Fenella J Rich  1 , Diane N Kenwright  1 , Aaron J Stevens  2
Affiliations
Free article
Review

Epigenetic changes associated with Bacillus Calmette-Guerin (BCG) treatment in bladder cancer

Lucy C Picard et al. Biochim Biophys Acta Rev Cancer. 2024 Sep.
Free article

Abstract

Bacillus Calmette-Guérin (BCG) treatment for non-muscle invasive bladder cancer (NMIBC) is an established immunotherapeutic, however, a significant portion of patients do not respond to treatment. Despite extensive research into the therapeutic mechanism of BCG, gaps remain in our understanding. This review specifically focuses on the epigenomic contributions in the immune microenvironment, in the context of BCG treatment for NMIBC. We also summarise the current understanding of NMIBC epigenetic characteristics, and discuss how future targeted strategies for BCG therapy should incorporate epigenomic biomarkers in conjunction with genomic biomarkers.

Keywords: BCG; Bacillus Calmette-Guérin; Bladder cancer; Cancer; Cancer diagnostics; DNA methylation; Epigenetics; Immunology.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

MeSH terms

LinkOut - more resources