Translating regenerative medicine therapies in neonatal necrotizing enterocolitis

Niloofar Ganji^#^{1

2}, Brian Kalish^#^{3

4

5}, Martin Offringa^#^{5

6}, Bo Li², James Anderson⁷, Sylvain Baruchel², Martin Blakely⁸, Paolo De Coppi⁹, Simon Eaton⁹, Estelle Gauda⁵, Nigel Hall¹⁰, Anna Heath^{6

11

12}, Michael H Livingston¹³, Carol McNair¹⁴, Robert Mitchell¹⁵, Ketan Patel¹⁵, Petros Pechlivanoglou⁶, Hazel Pleasants-Terashita¹⁴, Erin Pryor¹⁶, Milica Radisic¹⁷, Prakesh S Shah¹⁸, Bernard Thébaud¹⁹, Kasper Wang²⁰, Augusto Zani²⁰, Agostino Pierro^{21

22

23

24}

Affiliations

¹ Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
² Translational Medicine, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada.
³ Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada.
⁴ Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
⁵ Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
⁶ Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
⁷ Departments of Bioethics, The Hospital for Sick Children, Toronto, ON, Canada.
⁸ Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
⁹ Stem Cells and Regenerative Medicine, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
¹⁰ University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
¹¹ Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
¹² Department of Statistical Science, University College London, London, UK.
¹³ McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
¹⁴ Neonatal Intensive Care Unit, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
¹⁵ Micregen Ltd, Thames Valley Science Park, Reading, UK.
¹⁶ NEC Society, 140 B St. Ste 5 #128, Davis, CA, USA.
¹⁷ Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
¹⁸ Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
¹⁹ Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
²⁰ Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
²¹ Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.
²² Translational Medicine, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.
²³ Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.
²⁴ Department of Physiology, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.

^# Contributed equally.

PMID: 38806665
PMCID: PMC11772243
DOI: 10.1038/s41390-024-03236-x

Translating regenerative medicine therapies in neonatal necrotizing enterocolitis

Niloofar Ganji et al. Pediatr Res. 2024 Dec.

. 2024 Dec;96(7):1609-1615.

doi: 10.1038/s41390-024-03236-x. Epub 2024 May 28.

Authors

Affiliations

¹ Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
² Translational Medicine, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada.
³ Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada.
⁴ Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
⁵ Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
⁶ Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
⁷ Departments of Bioethics, The Hospital for Sick Children, Toronto, ON, Canada.
⁸ Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
⁹ Stem Cells and Regenerative Medicine, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
¹⁰ University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
¹¹ Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
¹² Department of Statistical Science, University College London, London, UK.
¹³ McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
¹⁴ Neonatal Intensive Care Unit, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
¹⁵ Micregen Ltd, Thames Valley Science Park, Reading, UK.
¹⁶ NEC Society, 140 B St. Ste 5 #128, Davis, CA, USA.
¹⁷ Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
¹⁸ Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
¹⁹ Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
²⁰ Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
²¹ Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.
²² Translational Medicine, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.
²³ Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.
²⁴ Department of Physiology, University of Toronto, Toronto, ON, Canada. agostino.pierro@sickkids.ca.

^# Contributed equally.

PMID: 38806665
PMCID: PMC11772243
DOI: 10.1038/s41390-024-03236-x

No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: RM, PD, and KP are stockholders of Micregen Ltd. All other authors declare they have no conflict of interest.

Figures

**Fig. 1. NEC-ACCELERATOR uses an evidence-based multidisciplinary approach to enhance the success of safe and timely clinical translation of stem cell-based therapies for neonates with NEC.**
BM-MSC bone marrow-derived mesenchymal stem cells, UC-MSC umbilical cord-derived MSC, E-NSC enteric neural stem cells, AFSC amniotic fluid-derived stem cells, P-MSC placenta-derived MSC.

See this image and copyright information in PMC

References

1. Fitzgibbons, S. C. et al. Mortality of necrotizing enterocolitis expressed by birth weight categories. J. Pediatr. Surg.44, 1072–1075 (2009). discussion 1075-1076. - PubMed
1. Hackam, D. J. & Sodhi, C. P. Bench to bedside - new insights into the pathogenesis of necrotizing enterocolitis. Nat. Rev. Gastroenterol. Hepatol.19, 468–479 (2022). - PubMed
1. Frost, B. L., Modi, B. P., Jaksic, T. & Caplan, M. S. New Medical and Surgical Insights Into Neonatal Necrotizing Enterocolitis: A Review. JAMA Pediatr.171, 83–88 (2017). - PubMed
1. Sampath, V., Martinez, M., Caplan, M., Underwood, M. A. & Cuna, A. Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies. Mucosal Immunol.16, 208–220 (2023). - PMC - PubMed
1. Hall, N. & Pierro, A. Necrotizing enterocolitis. Hosp. Med.65, 220–225 (2004). - PubMed

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
- PubMed Central

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Translating regenerative medicine therapies in neonatal necrotizing enterocolitis

Affiliations

Translating regenerative medicine therapies in neonatal necrotizing enterocolitis

Authors

Affiliations

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources