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Multicenter Study
. 2024 Oct;20(10):1070-1078.
doi: 10.1007/s12519-024-00813-2. Epub 2024 May 28.

Attention deficit hyperactivity disorder in children with epilepsy: a multicenter cross-sectional analysis in China

Gang Pan  1 , Ying Han  2 , Tian-Cheng Wang  3 , Zi-Yi Chen  4 , Xiang-Qing Wang  5 , Hong-Bin Sun  6 , Yong-Hong Liu  7 , Qun Wang  8 , Wei-Hong Lin  9 , Jin-Mei Li  10 , Shui-Zhen Zhou  11 , Yue-Hua Zhang  12
Affiliations
Multicenter Study

Attention deficit hyperactivity disorder in children with epilepsy: a multicenter cross-sectional analysis in China

Gang Pan et al. World J Pediatr. 2024 Oct.

Abstract

Background: The diagnosis and treatment of attention deficit hyperactivity disorder (ADHD) comorbid with epilepsy have been insufficiently addressed in China. We conducted a study in China to investigate the current status, diagnosis, and treatment of ADHD in children to further our understanding of ADHD comorbid with epilepsy, strengthen its management, and improve patients' quality of life.

Methods: We carried out a multicenter cross-sectional survey of children with epilepsy across China between March 2022 and August 2022. We screened all patients for ADHD and compared various demographic and clinical factors between children with and without ADHD, including gender, age, age at epilepsy onset, duration of epilepsy, seizure types, seizure frequency, presence of epileptiform discharges, and treatment status. Our objective was to explore any possible associations between these characteristics and the prevalence of ADHD.

Results: Overall, 395 epilepsy patients aged 6-18 years were enrolled. The age at seizure onset and duration of epilepsy ranged from 0.1-18 to 0.5-15 years, respectively. Focal onset seizures were observed in 212 (53.6%) patients, while 293 (76.3%) patients had epileptiform interictal electroencephalogram (EEG) abnormalities. Among the 370 patients treated with anti-seizure medications, 200 (54.1%) had monotherapy. Although 189 (47.8%) patients had ADHD, only 31 received treatment for it, with the inattentive subtype being the most common. ADHD was more common in children undergoing polytherapy compared to those on monotherapy. Additionally, poor seizure control and the presence of epileptiform interictal EEG abnormalities may be associated with a higher prevalence of ADHD.

Conclusions: While the prevalence of ADHD was higher in children with epilepsy than in normal children, the treatment rate was notably low. This highlights the need to give more importance to the diagnosis and treatment of ADHD in children with epilepsy.

Keywords: Attention deficit hyperactivity disorder; Children; China; Electroencephalogram; Epilepsy.

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References

    1. Guidelines for epidemiologic studies on epilepsy. Commission on epidemiology and prognosis, international league against epilepsy. Epilepsia. 1993;34:592–6. - DOI
    1. Mac TL, Tran DS, Quet F, Odermatt P, Preux PM, Tan CT. Epidemiology, aetiology, and clinical management of epilepsy in Asia: a systematic review. Lancet Neurol. 2007;6:533–43. - DOI - PubMed
    1. Ba-Diop A, Marin B, Druet-Cabanac M, Ngoungou EB, Newton CR, Preux PM. Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol. 2014;13:1029–44. - DOI - PubMed - PMC
    1. Banerjee PN, Filippi D, Allen HW. The descriptive epidemiology of epilepsy—a review. Epilepsy Res. 2009;85:31–45. - DOI - PubMed - PMC
    1. Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia. 2010;51:883–90. - DOI - PubMed - PMC

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