Review

. 2024 Sep;82(3):1613-1627.

doi: 10.1007/s12013-024-01317-6. Epub 2024 May 28.

Relationship between lncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths

Ahmed Hjazi¹, Saade Abdalkareem Jasim², Farag M A Altalbawy³, Harpreet Kaur^{4

5}, Hamza Fadhel Hamzah⁶, Irwanjot Kaur^{7

8}, Mahamedha Deorari⁹, Abhinav Kumar¹⁰, Ahmed Elawady^{11

12

13}, Mohammed N Fenjan¹⁴

Affiliations

¹ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
² Medical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq. Saad.A.J.Anbar@gmail.com.
³ Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.
⁴ School of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
⁵ Department of Health & Allied Sciences, Arka Jain University, Jamshedpur, Jharkhand, 831001, India.
⁶ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
⁷ Department of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bangalore, Karnataka, India.
⁸ Faculty of Health and Life Sciences, Management and Science University, Shah Alam, Malaysia.
⁹ Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
¹⁰ Department of Nuclear and Renewable Energy, Ural Federal University Named after the First President of Russia Boris Yeltsin, Ekaterinburg, 620002, Russia.
¹¹ College of Technical Engineering, the Islamic University, Najaf, Iraq.
¹² College of technical engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹³ College of Technical Engineering, the Islamic University of Babylon, Babylon, Iraq.
¹⁴ College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.

PMID: 38806965
DOI: 10.1007/s12013-024-01317-6

Review

Relationship between lncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths

Ahmed Hjazi et al. Cell Biochem Biophys. 2024 Sep.

. 2024 Sep;82(3):1613-1627.

doi: 10.1007/s12013-024-01317-6. Epub 2024 May 28.

Authors

Affiliations

¹ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
² Medical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq. Saad.A.J.Anbar@gmail.com.
³ Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.
⁴ School of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
⁵ Department of Health & Allied Sciences, Arka Jain University, Jamshedpur, Jharkhand, 831001, India.
⁶ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
⁷ Department of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bangalore, Karnataka, India.
⁸ Faculty of Health and Life Sciences, Management and Science University, Shah Alam, Malaysia.
⁹ Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
¹⁰ Department of Nuclear and Renewable Energy, Ural Federal University Named after the First President of Russia Boris Yeltsin, Ekaterinburg, 620002, Russia.
¹¹ College of Technical Engineering, the Islamic University, Najaf, Iraq.
¹² College of technical engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹³ College of Technical Engineering, the Islamic University of Babylon, Babylon, Iraq.
¹⁴ College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.

PMID: 38806965
DOI: 10.1007/s12013-024-01317-6

Abstract

The advancement of novel technologies, coupled with bioinformatics, has led to the discovery of additional genes, such as long noncoding RNAs (lncRNAs), that are associated with drug resistance. LncRNAs are composed of over 200 nucleotides and do not possess any protein coding function. These lncRNAs exhibit lower conservation across species, are typically expressed at low levels, and often display high specificity towards specific tissues and developmental stages. The LncRNA MALAT1 plays crucial regulatory roles in various aspects of genome function, encompassing gene transcription, splicing, and epigenetics. Additionally, it is involved in biological processes related to the cell cycle, cell differentiation, development, and pluripotency. Recently, MALAT1 has emerged as a novel mechanism contributing to drug resistance or sensitivity, attracting significant attention in the field of cancer research. This review aims to explore the mechanisms through which MALAT1 confers resistance to chemotherapy and radiotherapy in cancer cells.

Keywords: Cancer; Chemo-radiotherapy; LncRNA; MALAT1; Resistance.

PubMed Disclaimer

Cited by

Radio-chemotherapy and metformin selectively modulate the heterogeneous landscape of glioma with ribosome biogenesis, long non coding RNA and immune-escape markers as major player.
Valtorta S, Granata S, de Pretis S, Bertoli G, Redaelli S, Berno V, Spinelli AE, Diprima S, Rainone P, Coliva A, Todde S, Marfia G, Navone S, Caroli M, Bentivegna A, Di Muzio N, Moresco RM. Valtorta S, et al. Int J Biol Sci. 2025 May 27;21(8):3527-3554. doi: 10.7150/ijbs.103194. eCollection 2025. Int J Biol Sci. 2025. PMID: 40520013 Free PMC article.
Investigation of Non-Coding RNA-Related Autophagy Alterations in Drug-Resistant Multiple Myeloma Plasma Cells.
Sarafraznia L, Tahan Nejad Asadi Z, Dayer D, Jalalifar MA, Ghanatir N. Sarafraznia L, et al. Iran J Pathol. 2024 Fall;19(4):422-430. doi: 10.30699/ijp.2024.2022061.3256. Epub 2024 Oct 2. Iran J Pathol. 2024. PMID: 40034935 Free PMC article.
Gene expression profiling of lncRNA-HOTAIR and lncRNA-MALAT1 in esophageal cancer: uncovering links to lifestyle factors and diagnostic significance.
Ghorbani V, Ghorbian S. Ghorbani V, et al. Discov Oncol. 2025 Apr 28;16(1):630. doi: 10.1007/s12672-025-02465-8. Discov Oncol. 2025. PMID: 40295320 Free PMC article.

References

1. Petit, C., Lacas, B., Pignon, J. P., Le, Q. T., Grégoire, V., & Grau, C. et al.(2021). Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis. The Lancet Oncology, 22, 727–736. - PubMed - DOI
1. Kokka, F., Bryant, A., Olaitan, A., Brockbank, E., Powell, M., & Oram, D. (2022). Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. The Cochrane Database of Systematic Reviews, 8, Cd010260 - PubMed
1. Hickey, B. E., Francis, D. P., Lehman, M. (2013). Sequencing of chemotherapy and radiotherapy for early breast cancer. Cochrane Database Systematic Reviews. 30, Cd005212.
1. Haussmann, J., Tamaskovics, B., Bölke, E., Djiepmo-Njanang, F. J., Kammers, K., & Corradini, S., et al. (2019). Addition of chemotherapy to hyperfractionated radiotherapy in advanced head and neck cancer-a meta-analysis. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft, 195, 1041–1049. - DOI
1. Najafi, S. (2022). Circular RNAs as emerging players in cervical cancer tumorigenesis; A review to roles and biomarker potentials. International Journal of Biological Macromolecules, 206, 939–953. - PubMed - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

PSAU/2023/R/1445/Prince Sattam bin Abdulaziz University

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Relationship between lncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths

Affiliations

Relationship between lncRNA MALAT1 and Chemo-radiotherapy Resistance of Cancer Cells: Uncovered Truths

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical