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Randomized Controlled Trial
. 2024 Jun;30(6):e13766.
doi: 10.1111/srt.13766.

Evaluation and comparison of the efficacy and safety of the combination of topical phenytoin and microneedling with microneedling alone in the treatment of atrophic acne scars: A controlled blinded randomized clinical trial

Afsaneh Sadeghzadeh-Bazargan  1 , Arezoo Pashaei  1 , Mohammadreza Ghassemi  1 , Abbas Dehghani  1 , Mojtaba Shafiei  1 , Azadeh Goodarzi  1
Affiliations
Randomized Controlled Trial

Evaluation and comparison of the efficacy and safety of the combination of topical phenytoin and microneedling with microneedling alone in the treatment of atrophic acne scars: A controlled blinded randomized clinical trial

Afsaneh Sadeghzadeh-Bazargan et al. Skin Res Technol. 2024 Jun.

Retraction in

Abstract

Introduction: Severe acne breakouts often lead to atrophic acne scars, which affect millions of people worldwide and can significantly affect a person's self-confidence and self-image. Given the difficulty in treating atrophic acne scars, this study aims to investigate the efficacy of topical phenytoin in the treatment of atrophic acne scars.

Method: This split face clinical trial on 25 patients between the ages of 18 and 40 involved the application of microneedling on one side of the face, with three sessions taking place over the course of a month. On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. Baseline information was collected for all patients, and follow-up assessments were conducted during the treatment sessions and 2 months after the last session. The assessments included evaluating the number and area of pores and spots, determining scar severity, assessing patient satisfaction, and recording any potential complications.

Results: Among patients, 20 individuals (80%) were females, and the average age of the participants was 35.96 ± 9.23. In terms of the fine pore area, despite the fine pore count, both groups showed improvement over time (p: 0.03 vs. 0.06). Also, regarding large pore count and area, and the count and area of spots, both groups showed improvement over time (p: 0.001). However, there were no significant differences between the two groups (p > 0.05). On the other hand, when it comes to acne scar grade and patients' satisfaction, the phenytoin group outperformed the control group in all follow-up sessions and this difference was found to be significant (p: 0.001). It is worth noting that no complications were observed among any of the patients.

Conclusion: It appears that combining phenytoin cream with microneedling has a more effective therapeutic outcome in enhancing atrophic acne scars, when compared to microneedling alone, and this method can be regarded as a viable alternative in treating these types of scars.

Keywords: acne; acne scar; atrophic scar; clinical trial; efficacy; microneedling; phenytoin; safety; topical phenytoin.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
The count and area of the fine and large pores; right: microneedling + topical phenytoin, left: microneedling alone.
FIGURE 2
FIGURE 2
Comparison of severity indices in two groups over time.
See this image and copyright information in PMC

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