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Review
. 2025;13(4):712-725.
doi: 10.2174/0122117385303596240513053014.

Ethosome: An Innovative Perspective of Drug Delivery

Nilam Santosh Lohakare  1 , Vaibhav Gulabrao Bhamare  2 , Nikhil Dadaji Chavan  1 , Shruti Dnyaneshwar Shelar  1 , Harshal Dattatray Mahajan  1 , Rakesh Devidas Amrutkar  3
Affiliations
Review

Ethosome: An Innovative Perspective of Drug Delivery

Nilam Santosh Lohakare et al. Pharm Nanotechnol. 2025.

Abstract

Ethosome offers a unique solution to the challenges faced by conventional drug delivery systems. In comparison to traditional liposomes and other nanocarriers, ethosomes exhibit a unique ability to improve drug absorption, overcoming a major limitation in the Transdermal Drug Delivery System. Their soft and flexible nano-vesicular structure facilitates faster permeation, resulting in significantly higher transdermal flux. This scientific investigation effectively traverses the changing landscape of ethosomes as an innovative drug delivery system. By conducting a thorough comparative analysis, we uncover the distinct characteristics that set them apart from other nanocarriers, offering insights into their distinct advantages. The study also includes a detailed analysis of the variables that have a complex impact on performance, elucidating transport mechanisms and addressing advanced facets pivotal for refined drug delivery strategies. This comprehensive overview highlights ethosomes as a future of medicine, offering a promising future for the safe and effective treatment of diverse diseases, impacting numerous lives.

Keywords: Ethosomes; drug delivery system; nanocarrier; phospholipid; stratum corneum; vesicles..

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References

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