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. 2024 May 1;25(5):1507-1513.
doi: 10.31557/APJCP.2024.25.5.1507.

Human Leukocyte Antigen Alleles (HLA-A, HLA-B, and HLA-DRB1) are associated with Acute Lymphoblastic Leukemia (ALL) : A Case-Control Study in a Sample of Iranian Population

Mahdi Kohansal Vajari  1   2 , Mohsen Ehsan  2   3 , Saeedeh Ghiasi  2 , Saba Fooladi  4   5 , Najibe Karami  2   6 , Gholamhossein Hassanshahi  2 , Ahmad Fatemi  7
Affiliations

Human Leukocyte Antigen Alleles (HLA-A, HLA-B, and HLA-DRB1) are associated with Acute Lymphoblastic Leukemia (ALL) : A Case-Control Study in a Sample of Iranian Population

Mahdi Kohansal Vajari et al. Asian Pac J Cancer Prev. .

Abstract

Objective: This study seeks to elucidate the association between HLA-A, HLA-B, and HLA-DRB1 alleles and their relative risk contributions to ALL within an Iranian cohort.

Methods: Utilizing a robust case-control design, this research involved 71 ALL patients and 71 age and sex-matched healthy individuals. Genotyping of specified HLA alleles was performed using the advanced PCR-SSP technique.

Results: Our findings reveal a marked increase in the prevalence of the HLA-DRB1*04 allele among patients diagnosed with ALL compared to the control group (P<0.027). Conversely, the alleles HLA-A*26 (P=0.025), HLA-A*33 (P=0.020), and HLA-DRB1*03 (P=0.035) were observed at significantly reduced frequencies within the patient population.

Conclusion: Our findings highlight HLA-DRB1*04 as a potential genetic marker for increased susceptibility to ALL, while HLA-A*26, HLA-A*33, and HLA-DRB1*03 emerge as protective factors.

Keywords: Acute Lymphoblastic Leukemia; HLA Alleles; Iranian population; PCR-SSP.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Representative Result of PCR-SSP for HLA Typing.
See this image and copyright information in PMC

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