Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 1;14(2):e2024104.
doi: 10.5826/dpc.1402a104.

Correlation of Specific Inflammatory Markers With the Occurrence of Depression in Patients With Psoriasis and Their Use as Biomarkers for the Diagnosis of Depression

Eleni Mitsiou  1 , Aikaterini Kyriakou  1 , Eleni Parlapani  2 , Anastasia Trigoni  1 , Myrto Trakatelli  1 , Zoe Apalla  1 , Dimitrios Sotiriadis  1 , Elizabeth Lazaridou  1 , Aikaterini Patsatsi  1
Affiliations

Correlation of Specific Inflammatory Markers With the Occurrence of Depression in Patients With Psoriasis and Their Use as Biomarkers for the Diagnosis of Depression

Eleni Mitsiou et al. Dermatol Pract Concept. .

Abstract

Introduction: Psoriasis is a systemic disease of the skin and nails associated with a wide range of comorbidities such as depression, psoriatic arthritis and metabolic syndrome.

Objectives: The study aimed to examine a potential association between inflammatory markers (C- reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and depression in patients with psoriasis.

Methods: A total of 80 individuals were enrolled in the study. Case participants included 28 patients diagnosed with Psoriasis (Beck Depression Inventory-II: :0-13) and 24 patients diagnosed with Psoriasis and Depression (Beck Depression Inventory-II:14-63). Twenty-eight (28) healthy participants comprised the control group.Psoriasis severity was evaluated by using Psoriasis Area and Severity Index, Physician Global Assessment, Body Surface Area and Dermatology Life Quality Index. Written approval was obtained for its use in this study: Cardiff University (09/2015). Other factors considered in the study were obesity using the Body Mass Index, the levels of stress using the Beck Anxiety Inventory, and the presence of insomnia using the Athens Insomnia Scale. Blood draws and inflammatory markers measurements were performed for all participants.

Results: Both CRP and ESR levels were higher in the case group (ie Psoriasis and Depression and Psoriasis) compared to healthy controls. Furthermore, psoriatic patients with depression showed increased CRP and ESR levels compared to those of psoriatic patients without depression.

Conclusions: The evaluation of both CRP and ESR and their use to detect the presence of depression in patients with psoriasis can be an important tool for their holistic treatment of theirs.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: None.

Figures

Figure 1
Figure 1
Comparative boxplot of erythrocyte sedimentation rate (ESR) baseline values.
Figure 2
Figure 2
Comparative boxplot of C- reactive protein (CRP) baseline values.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Global report on psoriasis. World Health Organization; Oct 26, 2016. p. 10.
    1. PrCEMGriffiths MD, et al. Psoriasis, lancet. 2021 april 3;397
    1. Chen L, Shen Z. Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders. Cell Mol Immunol. 2020;17(1):64–75. doi: 10.1038/s41423-019-0291-4. - DOI - PMC - PubMed
    1. Palijan TZ, Kovacević D, Koić E, Ruzić K, Dervinja F. The impact of psoriasis on the quality of life and psychological characteristics of persons suffering from psoriasis. Coll Antropol. 2011;35(Suppl 2):81–85. - PubMed
    1. Han C, Lofland JH, Zhao N, Schenkel B. Increased prevalence of psychiatric disorders and health care-associated costs among patients with moderate-to-severe psoriasis. J Drugs Dermatol. 2011;10(8):843–850. - PubMed