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. 2024 Jun 13;390(22):2124-2127.
doi: 10.1056/NEJMc2402779. Epub 2024 May 29.

Durability of XBB.1.5 Vaccines against Omicron Subvariants

Dan-Yu Lin  1 , Yi Du  2 , Yangjianchen Xu  3 , Sai Paritala  4 , Matthew Donahue  4 , Patrick Maloney  5
Affiliations

Durability of XBB.1.5 Vaccines against Omicron Subvariants

Dan-Yu Lin et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Effectiveness of the XBB.1.5 vaccines against omicron subvariants as a function of time since vaccination.
The first, second, third, and fourth rows pertain to the endpoints of infection, hospitalization, hospitalization or death, and death, respectively. The left column pertains to the analysis of all vaccine doses, and the right column pertains to the stratified analysis by vaccination cohort (i.e., receipt date of the XBB.1.5 vaccine). The solid curves show the estimates of vaccine effectiveness. The shaded bands indicate 95% confidence intervals. In (B), (D), (F), and (H), each curve starts at the median receipt date of the XBB.1.5 vaccine for persons in that cohort, and the proportions of XBB.1.5, other XBB, JN.1, and other subvariants are indicated by the purple, coral, green, and cyan areas, respectively.
See this image and copyright information in PMC

References

    1. Food and Drug Administration. FDA Takes Action on Updated mRNA COVID-19 Vaccines to Better Protect Against Currently Circulating Variants. Press release, September 11, 2023 (https://www.fda.gov/news-events/press-announcements/fda-takes-action-upd...),
    1. Food and Drug Administration. FDA Authorizes Updated Novavax COVID-19 Vaccine Formulated to Better Protect Against Currently Circulating Variants. Pres release, October 03, 2023 (https://www.fda.gov/news-events/press-announcements/fda-authorizes-updat...).
    1. Lin DY, Xu Y, Gu Y, et al. Durability of bivalent boosters against new omicron subvariants. N Engl J Med, 2023; 388:1818–1820. - PMC - PubMed

Publication types

Supplementary concepts