Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

doi:10.1016/j.jnha.2024.100268

. 2024 Jun;28(6):100268.

doi: 10.1016/j.jnha.2024.100268. Epub 2024 May 28.

Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

Pi-Shan Hsu¹, Wei-Ju Lee², Li-Ning Peng³, Wan-Hsuan Lu⁴, Lin-Chieh Meng⁵, Fei-Yuan Hsiao⁶, Liang-Kung Chen⁷

Affiliations

¹ Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
² Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan; Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, Yi-Lan County, Taiwan.
³ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
⁴ Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France; Maintain Aging Research team, Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Inserm, Université Paul Sabatier, Toulouse, France.
⁵ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁶ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: fyshsiao@ntu.edu.tw.
⁷ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan. Electronic address: lkchen2@vghtpe.gov.tw.

PMID: 38810513
PMCID: PMC12275728
DOI: 10.1016/j.jnha.2024.100268

Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

Pi-Shan Hsu et al. J Nutr Health Aging. 2024 Jun.

. 2024 Jun;28(6):100268.

doi: 10.1016/j.jnha.2024.100268. Epub 2024 May 28.

Authors

Pi-Shan Hsu¹, Wei-Ju Lee², Li-Ning Peng³, Wan-Hsuan Lu⁴, Lin-Chieh Meng⁵, Fei-Yuan Hsiao⁶, Liang-Kung Chen⁷

Affiliations

¹ Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
² Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan; Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, Yi-Lan County, Taiwan.
³ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
⁴ Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France; Maintain Aging Research team, Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Inserm, Université Paul Sabatier, Toulouse, France.
⁵ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
⁶ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: fyshsiao@ntu.edu.tw.
⁷ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan. Electronic address: lkchen2@vghtpe.gov.tw.

PMID: 38810513
PMCID: PMC12275728
DOI: 10.1016/j.jnha.2024.100268

Abstract

Background: Sarcopenia and intrinsic capacity (IC) declines pose significant challenges to healthy aging, particularly in the rapidly growing octogenarian population. This study aimed to elucidate the relationship between sarcopenia and declines in IC across multiple cohorts of community-dwelling older adults.

Methods: Data from four Taiwanese cohorts were analyzed. Sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia (AWGS) 2019 criteria (algorithm 1: categorized as either having possible sarcopenia or not (robust); algorithm 2: categorized as robust, possible sarcopenia or sarcopenia). IC was operationalized using the World Health Organization's Integrated Care for Older People (ICOPE) framework (step 1 and step 2), encompassing six domains: locomotion, vitality, vision, hearing, cognition, and psychological well-being. Multivariable logistic regression models were adopted to assess the association between sarcopenia and IC decline.

Results: Among 599 octogenarians (median age 82.2 years, 54.8% male), the prevalence of possible sarcopenia (algorithm 1) was 64.6%. When adopting algorithm 2, the prevalence of possible sarcopenia and sarcopenia was 46,2% and 32.1%, respectively. After adjusting for covariates, participants with possible sarcopenia or sarcopenia (algorithm 2) were more likely to exhibit declines in vitality (ICOPE Step 1: possible sarcopenia aOR 3.65, sarcopenia aOR 4.74; ICOPE Step 2: possible sarcopenia aOR 5.11, sarcopenia aOR 14.77) and cognition (ICOPE Step 1: possible sarcopenia aOR 2.40, sarcopenia aOR 2.12; ICOPE Step 2: possible sarcopenia aOR 2.02, sarcopenia aOR 2.51) compared to robust individuals.

Conclusions: This study underscores the robust association between sarcopenia and declines in vitality and cognition among octogenarians, highlighting the importance of sarcopenia screening and management in promoting healthy longevity in this vulnerable population.

Keywords: Cohort; Intrinsic capacity; Octogenarians; Older adults; Sarcopenia; Vitality and cognition.

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References

1. United Nations Department of Economic and Social Affairs, Population Division (2022). World Population. Prospects 2022: Summary of Results. UN DESA/POP/2022/TR/NO. 3.
1. Chen L.K. The global landscape of geriatric medicine: successes and shortcomings. Arch Gerontol Geriatr. 2023;115 - PubMed
1. Diniz J.S., Nascimento D.D.C., Sousa Neto I.V., Alves V.P., Stone W., Prestes J., et al. Muscle performance in octogenarians: factors affecting dynapenia. J Bodyw Mov Ther. 2023;35:14–20. - PubMed
1. Franzon K., Byberg L., Sjögren P., Zethelius B., Cederholm T., Kilander L. Predictors of independent aging and survival: a 16-year follow-up report in octogenarian men. J Am Geriatr Soc. 2017;65(9):1953–1960. - PubMed
1. World Health Organization. (2019). Integrated care for older people (ICOPE): guidance for person-centred assessment and pathways in primary care. World Health Organization. https://iris.who.int/handle/10665/326843. (accessed March 14, 2024).

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[1] United Nations Department of Economic and Social Affairs, Population Division (2022). World Population. Prospects 2022: Summary of Results. UN DESA/POP/2022/TR/NO. 3.

[2] United Nations Department of Economic and Social Affairs, Population Division (2022). World Population. Prospects 2022: Summary of Results. UN DESA/POP/2022/TR/NO. 3.

[3] Chen L.K. The global landscape of geriatric medicine: successes and shortcomings. Arch Gerontol Geriatr. 2023;115 - PubMed

[4] Chen L.K. The global landscape of geriatric medicine: successes and shortcomings. Arch Gerontol Geriatr. 2023;115 - PubMed

[5] Diniz J.S., Nascimento D.D.C., Sousa Neto I.V., Alves V.P., Stone W., Prestes J., et al. Muscle performance in octogenarians: factors affecting dynapenia. J Bodyw Mov Ther. 2023;35:14–20. - PubMed

[6] Diniz J.S., Nascimento D.D.C., Sousa Neto I.V., Alves V.P., Stone W., Prestes J., et al. Muscle performance in octogenarians: factors affecting dynapenia. J Bodyw Mov Ther. 2023;35:14–20. - PubMed

[7] Franzon K., Byberg L., Sjögren P., Zethelius B., Cederholm T., Kilander L. Predictors of independent aging and survival: a 16-year follow-up report in octogenarian men. J Am Geriatr Soc. 2017;65(9):1953–1960. - PubMed

[8] Franzon K., Byberg L., Sjögren P., Zethelius B., Cederholm T., Kilander L. Predictors of independent aging and survival: a 16-year follow-up report in octogenarian men. J Am Geriatr Soc. 2017;65(9):1953–1960. - PubMed

[9] World Health Organization. (2019). Integrated care for older people (ICOPE): guidance for person-centred assessment and pathways in primary care. World Health Organization. https://iris.who.int/handle/10665/326843. (accessed March 14, 2024).

[10] World Health Organization. (2019). Integrated care for older people (ICOPE): guidance for person-centred assessment and pathways in primary care. World Health Organization. https://iris.who.int/handle/10665/326843. (accessed March 14, 2024).

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Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

Affiliations

Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

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