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Case Reports
. 2024 Oct;75(10):809-813.
doi: 10.1007/s00105-024-05364-1. Epub 2024 May 29.

[Drug reaction with eosinophilia and systemic symptoms (DRESS): a hypersensitivity reaction with various symptoms]

[Article in German]
A Hansel  1 , E Oms  2 , M Tronnier  2
Affiliations
Case Reports

[Drug reaction with eosinophilia and systemic symptoms (DRESS): a hypersensitivity reaction with various symptoms]

[Article in German]
A Hansel et al. Dermatologie (Heidelb). 2024 Oct.

Abstract
in English, German

Drug reaction with eosinophilia and systemic symptoms (DRESS) is an illness which is difficult to diagnose because of its various symptoms. In our case, a patient with small spotted exanthema with nearly erythroderma and eosinophilia presented to the emergency room. Systemic steroid therapy was started on suspicion of a drug reaction. Over the course of time, the patient's general condition deteriorated significantly and the patient developed cholecystitis, Staphylococcus aureus bacteremia, pneumonitis and cytomegalovirus reactivation. With this case report, we want to show that DRESS is a disease that is difficult to treat and can develop after a long delay.

Bei DRESS („drug reaction with eosinophilia and systemic symptoms“) handelt es sich um eine Erkrankung, die aufgrund von vielfältigen Symptomen schwer zu diagnostizieren ist. In unserem Fall stellte sich eine Patientin mit einem feinfleckigen Exanthem mit Suberythrodermie und laborchemischer Eosinophilie vor. Bei Verdacht auf eine Arzneimittelreaktion wurde eine systemische Steroidtherapie begonnen. Im Verlauf kam es zu einer deutlichen Verschlechterung des Allgemeinzustandes sowie Ausbildung einer Cholezystitis, einer Staphylococcus-aureus-Bakteriämie, einer Pneumonitis sowie einer Zytomegalievirus-Reaktivierung. Mit diesem Fall wollen wir zeigen, wie schwer das DRESS zu behandeln ist und dass es für einen langen Zeitraum lebensgefährlich sein kann.

Keywords: Adverse drug reaction; Allergy; Drug hypersensitivity syndrome; Eosinophilia; Immunosuppression.

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References

Literatur

    1. Hama N, Abe R, Gibson A et al (2022) Drug-Induced Hypersensitivity Syndrome (DIHS)/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis. J Allergy Clin Immunol Pract 10:1155–1167 - DOI - PubMed - PMC
    1. Kano Y, Tohyama M, Aihara M et al (2015) Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR). J Dermatol 42:276–282 - DOI - PubMed
    1. Kardaun SH, Sekula P, Valeyrie-Allanore L et al (2013) Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol 169:1071–1080 - DOI - PubMed
    1. Kardaun SH, Sidoroff A, Valeyrie-Allanore L et al (2007) Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 156(3):609–611 - DOI - PubMed
    1. Mizukawa Y, Hirahara K, Kano Y, Shiohara T (2019) Drug-induced hypersensitivity syndrome(DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) severity score: a useful tool for assessing disease severity and predicting fatal cytomegalovirus disease. J Am Acad Dermatol 80:670 (e8) - DOI - PubMed

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