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Review
. 2024:1470:31-55.
doi: 10.1007/5584_2024_802.

Fatty Acid Metabolism in Peroxisomes and Related Disorders

Katsuya Morito  1 , Hanif Ali  2 , Shigenobu Kishino  3 , Tamotsu Tanaka  4
Affiliations
Review

Fatty Acid Metabolism in Peroxisomes and Related Disorders

Katsuya Morito et al. Adv Exp Med Biol. 2024.

Abstract

One of the functions of peroxisomes is the oxidation of fatty acids (FAs). The importance of this function in our lives is evidenced by the presence of peroxisomal disorders caused by the genetic deletion of proteins involved in these processes. Unlike mitochondrial oxidation, peroxisomal oxidation is not directly linked to ATP production. What is the role of FA oxidation in peroxisomes? Recent studies have revealed that peroxisomes supply the building blocks for lipid synthesis in the endoplasmic reticulum and facilitate intracellular carbon recycling for membrane quality control. Accumulation of very long-chain fatty acids (VLCFAs), which are peroxisomal substrates, is a diagnostic marker in many types of peroxisomal disorders. However, the relationship between VLCFA accumulation and various symptoms of these disorders remains unclear. Recently, we developed a method for solubilizing VLCFAs in aqueous media and found that VLCFA toxicity could be mitigated by oleic acid replenishment. In this chapter, we present the physiological role of peroxisomal FA oxidation and the knowledge obtained from VLCFA-accumulating peroxisome-deficient cells.

Keywords: Cell toxicity; Oleic acid; Peroxisomal disorder; Very long-chain fatty acid; α-Oxidation; β-Oxidation.

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